Lamc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lamc1
laminin, gamma 1
MGI:99914

71 phenotypes from 8 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lamc1^Gt(Ex183)Byg/Lamc1^Gt(Ex183)Byg involves: 129P2/OlaHsd * C57BL/6	embryonic lethality between implantation and somite formation, complete penetrance	J:70273
Lamc1^tm1.1Ksek/Lamc1⁺ involves: 129 * C57BL * C57BL/6 * DBA	normal embryo phenotype	J:279595
	normal reproductive system phenotype	J:279595
Lamc1^tm1.1Ksek/Lamc1^tm1.1Ksek involves: 129 * C57BL * C57BL/6 * DBA	embryonic lethality, complete penetrance	J:279595
Lamc1^tm1.1Strl/Lamc1^tm1.1Strl either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)	normal behavior/neurological phenotype	J:199683
Lamc1^tm1Edg/Lamc1^tm1Edg involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal primitive endoderm morphology	J:52418
	absent visceral yolk sac	J:52418
	embryonic lethality between implantation and somite formation, complete penetrance	J:52418
Lamc1^tm1Strl/Lamc1^tm1.2Strl either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)	abnormal basement membrane morphology	J:199683
	abnormal quadriceps morphology	J:199683
	centrally nucleated skeletal muscle fibers	J:199683
	decreased skeletal muscle fiber diameter	J:199683
	decreased skeletal muscle mass	J:199683
	demyelination	J:199683
	increased Schwann cell number	J:199683
	limb grasping	J:199683
	paraparesis	J:199683
	skeletal muscle fiber atrophy	J:199683
Lamc1^tm1Strl/Lamc1^tm1Strl involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:86714
Lamc1^tm1Strl/Lamc1^tm1Strl Tg(Camk2a-cre)2Szi/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal axon radial sorting	J:86714
	abnormal dorsal spinal root morphology	J:86714
	abnormal myelination	J:86714
	abnormal peripheral nervous system regeneration	J:86714
	abnormal response to injury	J:86714
	abnormal Schwann cell morphology	J:86714
	abnormal sciatic nerve morphology	J:86714
	abnormal ventral spinal root morphology	J:86714
	forelimb paralysis	J:86714
	hindlimb paralysis	J:86714
	muscular atrophy	J:86714
	tremors	J:86714
Lamc1^tm1Strl/Lamc1^tm1Strl Tg(Mpz-cre)26Mes/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal axon radial sorting	J:86714
	abnormal myelination	J:86714
	abnormal sciatic nerve morphology	J:86714
	forelimb paralysis	J:86714
	tremors	J:86714
Lamc1^tm1Umr/Lamc1^tm1Umr either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal basement membrane morphology	J:76368
	abnormal bronchus morphology	J:76368
	abnormal epididymis morphology	J:76368
	abnormal kidney development	J:76368
	abnormal lung saccule morphology	J:76368
	abnormal Mullerian duct morphology	J:76368
	abnormal renal glomerular capsule morphology	J:76368
	abnormal renal glomerulus morphology	J:76368
	abnormal reproductive system morphology	J:76368
	abnormal ureter morphology	J:76368
	abnormal Wolffian duct morphology	J:76368
	absent kidney	J:76368
	absent metanephros	J:76368
	absent seminal vesicle	J:76368
	absent ureteric bud	J:76368
	absent uterus	J:76368
	absent vas deferens	J:76368
	decreased fetal size	J:76368
	decreased renal glomerulus number	J:76368
	embryonic lethality during organogenesis, incomplete penetrance	J:76368
	hydronephrosis	J:76368
	kidney cyst	J:76368
	kidney failure	J:76368
	kidney microaneurysm	J:76368
	neonatal lethality, complete penetrance	J:76368
	single kidney	J:76368
	small lung	J:76368
	thick lung-associated mesenchyme	J:76368
Lamc1^tm1Umr/Lamc1^tm1Umr involves: 129S1/Sv * 129X1/SvJ	abnormal basement membrane morphology	J:119018, J:124247
	abnormal Cajal-Retzius cell morphology	J:124247
	abnormal cerebral cortex morphology	J:119018, J:124247
	abnormal cortical plate morphology	J:119018
	abnormal meninges morphology	J:124247
	abnormal neural tube closure	J:124247
	abnormal neuron differentiation	J:124247
	abnormal radial glial cell morphology	J:119018, J:124247
	abnormal retina morphology	J:124247
	decreased body size	J:124247
	decreased brain size	J:124247
	exencephaly	J:124247
	intracranial hemorrhage	J:124247
	thin cerebral cortex	J:119018
Lamc1^tm1Umr/Lamc1^tm1Umr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal brain development	J:126065
Lamc1^tm2.1Ksek/Lamc1^tm2.1Ksek involves: 129 * C57BL/6 * C57BL/6J	normal embryo phenotype	J:279595
	normal reproductive system phenotype	J:279595

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24