Lamc1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lamc1
laminin, gamma 1
MGI:99914

71 phenotypes from 8 alleles in 9 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lamc1^Gt(Ex183)Byg/Lamc1^Gt(Ex183)Byg involves: 129P2/OlaHsd * C57BL/6	embryonic lethality between implantation and somite formation, complete penetrance	J:70273
Lamc1^tm1.1Ksek/Lamc1⁺ involves: 129 * C57BL * C57BL/6 * DBA	normal embryo phenotype	J:279595
	normal reproductive system phenotype	J:279595
Lamc1^tm1.1Ksek/Lamc1^tm1.1Ksek involves: 129 * C57BL * C57BL/6 * DBA	embryonic lethality, complete penetrance	J:279595
Lamc1^tm1.1Strl/Lamc1^tm1.1Strl either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)	normal behavior/neurological phenotype	J:199683
Lamc1^tm1Edg/Lamc1^tm1Edg involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal primitive endoderm morphology	J:52418
	absent visceral yolk sac	J:52418
	embryonic lethality between implantation and somite formation, complete penetrance	J:52418
Lamc1^tm1Strl/Lamc1^tm1.2Strl either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA)	abnormal basement membrane morphology	J:199683
	abnormal quadriceps morphology	J:199683
	centrally nucleated skeletal muscle fibers	J:199683
	decreased skeletal muscle fiber diameter	J:199683
	decreased skeletal muscle mass	J:199683
	demyelination	J:199683
	increased Schwann cell number	J:199683
	limb grasping	J:199683
	paraparesis	J:199683
	skeletal muscle fiber atrophy	J:199683
Lamc1^tm1Strl/Lamc1^tm1Strl involves: 129P2/OlaHsd * C57BL/6	no abnormal phenotype detected	J:86714
Lamc1^tm1Strl/Lamc1^tm1Strl Tg(Camk2a-cre)2Szi/0 involves: 129P2/OlaHsd * C57BL/6 * CBA	abnormal axon radial sorting	J:86714
	abnormal dorsal spinal root morphology	J:86714
	abnormal myelination	J:86714
	abnormal peripheral nervous system regeneration	J:86714
	abnormal response to injury	J:86714
	abnormal Schwann cell morphology	J:86714
	abnormal sciatic nerve morphology	J:86714
	abnormal ventral spinal root morphology	J:86714
	forelimb paralysis	J:86714
	hindlimb paralysis	J:86714
	muscular atrophy	J:86714
	tremors	J:86714
Lamc1^tm1Strl/Lamc1^tm1Strl Tg(Mpz-cre)26Mes/0 involves: 129P2/OlaHsd * C57BL/6 * FVB/N	abnormal axon radial sorting	J:86714
	abnormal myelination	J:86714
	abnormal sciatic nerve morphology	J:86714
	forelimb paralysis	J:86714
	tremors	J:86714
Lamc1^tm1Umr/Lamc1^tm1Umr either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	abnormal basement membrane morphology	J:76368
	abnormal bronchus morphology	J:76368
	abnormal epididymis morphology	J:76368
	abnormal kidney development	J:76368
	abnormal lung saccule morphology	J:76368
	abnormal Mullerian duct morphology	J:76368
	abnormal renal glomerular capsule morphology	J:76368
	abnormal renal glomerulus morphology	J:76368
	abnormal reproductive system morphology	J:76368
	abnormal ureter morphology	J:76368
	abnormal Wolffian duct morphology	J:76368
	absent kidney	J:76368
	absent metanephros	J:76368
	absent seminal vesicle	J:76368
	absent ureteric bud	J:76368
	absent uterus	J:76368
	absent vas deferens	J:76368
	decreased fetal size	J:76368
	decreased renal glomerulus number	J:76368
	embryonic lethality during organogenesis, incomplete penetrance	J:76368
	hydronephrosis	J:76368
	kidney cyst	J:76368
	kidney failure	J:76368
	kidney microaneurysm	J:76368
	neonatal lethality, complete penetrance	J:76368
	single kidney	J:76368
	small lung	J:76368
	thick lung-associated mesenchyme	J:76368
Lamc1^tm1Umr/Lamc1^tm1Umr involves: 129S1/Sv * 129X1/SvJ	abnormal basement membrane morphology	J:119018, J:124247
	abnormal Cajal-Retzius cell morphology	J:124247
	abnormal cerebral cortex morphology	J:119018, J:124247
	abnormal cortical plate morphology	J:119018
	abnormal meninges morphology	J:124247
	abnormal neural tube closure	J:124247
	abnormal neuron differentiation	J:124247
	abnormal radial glial cell morphology	J:119018, J:124247
	abnormal retina morphology	J:124247
	decreased body size	J:124247
	decreased brain size	J:124247
	exencephaly	J:124247
	intracranial hemorrhage	J:124247
	thin cerebral cortex	J:119018
Lamc1^tm1Umr/Lamc1^tm1Umr involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal brain development	J:126065
Lamc1^tm2.1Ksek/Lamc1^tm2.1Ksek involves: 129 * C57BL/6 * C57BL/6J	normal embryo phenotype	J:279595
	normal reproductive system phenotype	J:279595

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