Lamb2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Lamb2
laminin, beta 2
MGI:99916

38 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Lamb2^em1Jhm/Lamb2^em1Jhm involves: C57BL/6J * CBA/J	normal homeostasis/metabolism phenotype	J:280129
Lamb2^npht/Lamb2^npht involves: C57BL/6	abnormal kidney morphology	J:208069
	abnormal kidney physiology	J:208069
	abnormal renal tubule epithelium morphology	J:208069
	decreased body weight	J:208069
	decreased circulating serum albumin level	J:208069
	decreased circulating total protein level	J:208069
	increased circulating cholesterol level	J:208069
	increased circulating triglyceride level	J:208069
	increased renal glomerulus basement membrane thickness	J:208069
	increased urine protein level	J:208069
Lamb2^tm1Jrs/Lamb2^tm1Jrs involves: 129S1/Sv * 129X1/SvJ	abnormal eye electrophysiology	J:77308
	abnormal glomerular filtration barrier function	J:27732
	abnormal miniature endplate potential	J:23783
	abnormal neuromuscular synapse morphology	J:23783
	abnormal renal glomerulus basement membrane morphology	J:27732
	abnormal retina morphology	J:77308
	abnormal retina outer plexiform layer morphology	J:77308
	abnormal retina photoreceptor morphology	J:77308
	abnormal retina rod cell morphology	J:77308
	albuminuria	J:27732
	decreased total retina thickness	J:77308
	failure of neuromuscular synapse postsynaptic differentiation	J:23783
	failure of neuromuscular synapse presynaptic differentiation	J:23783
	fused podocyte foot processes	J:23783
	glomerulonephritis	J:23783
	increased renal glomerulus basement membrane thickness	J:27732
	increased retina apoptosis	J:77308
	increased urine protein level	J:23783, J:27732
	lethargy	J:77308
	postnatal growth retardation	J:23783, J:27732
	postnatal lethality, complete penetrance	J:23783
	short photoreceptor inner segment	J:77308
	short photoreceptor outer segment	J:77308
Lamb2^tm1Jrs/Lamb2^tm1Jrs involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	abnormal amacrine cell morphology	J:169656
	abnormal eye physiology	J:169656
	abnormal Muller cell morphology	J:169656
	abnormal retina development	J:169656
	abnormal retina inner limiting membrane morphology	J:169656
	abnormal retina morphology	J:169656
	decreased amacrine cell number	J:169656

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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