Slc1a3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc1a3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
MGI:99917

30 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc1a3^{tm1.1(KOMP)Mbp}/Slc1a3⁺ C57BL/6N-Slc1a3^{tm1.1(KOMP)Mbp}/Ucd	abnormal sleep behavior	J:211773
	increased vertical activity	J:211773
Slc1a3^tm1Kta/Slc1a3^tm1Kta B6.129P2-Slc1a3^tm1Kta	abnormal electroretinogram waveform feature	J:124191
	abnormal optic nerve morphology	J:124191
	abnormal retina ganglion layer morphology	J:124191
	abnormal retina inner nuclear layer morphology	J:124191
	decreased retina ganglion cell number	J:124191
	increased cellular sensitivity to hydrogen peroxide	J:124191
	increased lactate dehydrogenase level	J:124191
	optic nerve cupping	J:124191
	optic nerve degeneration	J:124191
	retina degeneration	J:124191
	normal vision/eye phenotype	J:124191
Slc1a3^tm1Kta/Slc1a3^tm1Kta involves: 129P2/OlaHsd	abnormal auditory brainstem response waveform shape	J:66146
	abnormal kindling response	J:58180
	abnormal motor coordination/balance	J:46746
	abnormal nervous system physiology	J:46746
	abnormal Purkinje cell morphology	J:46746
	abnormal synaptic glutamate release	J:66146
	normal behavior/neurological phenotype	J:46746
	cochlear inner hair cell degeneration	J:99715
	increased or absent threshold for auditory brainstem response	J:66146
	increased susceptibility to noise-induced hearing loss	J:66146
	increased susceptibility to ototoxicity-induced hearing loss	J:99715
	increased susceptibility to pharmacologically induced seizures	J:58180
	normal nervous system phenotype	J:46746
	seizures	J:58180
Slc1a3^tm1Wst/Slc1a3^tm1Wst involves: 129S1/Sv * 129X1/SvJ	abnormal excitatory postsynaptic currents	J:93201
	prolonged excitatory postsynaptic current decay time	J:93201
	short excitatory postsynaptic current rise time	J:93201

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24