Vcp Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Vcp
valosin containing protein
MGI:99919

63 phenotypes from 6 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Vcp^em1Kene/Vcp⁺ C57BL/6J-Vcp^em1Kene	normal cellular phenotype	J:325062
	decreased body weight	J:325062
	decreased susceptibility to diet-induced obesity	J:325062
	normal growth/size/body region phenotype	J:325062
	normal homeostasis/metabolism phenotype	J:325062
	increased circulating triglyceride level	J:325062
	increased insulin sensitivity	J:325062
	increased susceptibility to diet-induced obesity	J:325062
Vcp^{Gt(OST196720)Lex}/Vcp^{Gt(OST196720)Lex} involves: 129S5/SvEvBrd * C57BL/6J	preweaning lethality, complete penetrance	J:103485
Vcp^tm1.1Dts/Vcp^tm1.1Dts either: (involves: 129P2/OlaHsd * C57BL/6 * FVB/N) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1 * FVB/N)	embryonic lethality before implantation, complete penetrance	J:118184
Vcp^tm1.1Hiok/Vcp⁺ B6(Cg)-Vcp^tm1.1Hiok	abnormal cell cycle checkpoint function	J:308471
	abnormal cerebral cortex morphology	J:308471
	abnormal cerebral cortex pyramidal cell morphology	J:308471
	abnormal DNA repair	J:308471
	abnormal endoplasmic reticulum morphology	J:308471
	abnormal frontal lobe morphology	J:308471
	abnormal primary motor cortex morphology	J:308471
	abnormal stratification in cerebral cortex	J:308471
	cellular necrosis	J:308471
	normal cellular phenotype	J:308471
	decreased brain weight	J:308471
	decreased dendritic spine number	J:308471
	decreased neuronal stem cell self-renewal	J:308471
	fast extinction of fear memory	J:308471
	impaired spatial learning	J:308471
	increased anxiety-related response	J:308471
	increased body weight	J:308471
	microcephaly	J:308471
	thin cerebral cortex	J:308471
Vcp^tm1Dts/Vcp^tm1.1Dts involves: 129P2/OlaHsd * C57BL/6 * FVB/N	embryonic lethality before implantation, complete penetrance	J:118184
Vcp^tm1Dts/Vcp^tm1Dts involves: 129P2/OlaHsd * C57BL/6	embryonic lethality before implantation, complete penetrance	J:118184
Vcp^tm1Itl/Vcp⁺ B6.129S-Vcp^tm1Itl	abnormal autophagy	J:166230
	abnormal neuron morphology	J:166230
	abnormal osteoclast differentiation	J:166230
	abnormal skeletal muscle fiber morphology	J:166230
	normal behavior/neurological phenotype	J:166230
	centrally nucleated skeletal muscle fibers	J:166230
	decreased bone mass	J:166230
	decreased grip strength	J:166230
	decreased trabecular bone connectivity density	J:166230
	impaired coordination	J:166230
	increased compact bone thickness	J:166230
	increased osteoclast cell number	J:166230
	increased variability of skeletal muscle fiber size	J:166230
	myopathy	J:166230
	progressive muscle weakness	J:166230
	seizures	J:166230
	tonic-clonic seizures	J:166230
Vcp^tm1Itl/Vcp^tm1Itl involves: 129S6/SvEvTac	abnormal autophagy	J:191963
	abnormal brain morphology	J:191963
	abnormal heart morphology	J:191963
	abnormal limb bone morphology	J:191963
	abnormal mitochondrial crista morphology	J:191963
	abnormal sarcomere morphology	J:191963
	abnormal skeletal muscle fiber morphology	J:191963
	abnormal skeletal muscle morphology	J:191963
	centrally nucleated skeletal muscle fibers	J:191963
	decreased body size	J:191963
	decreased body weight	J:191963
	decreased grip strength	J:191963
	decreased skeletal muscle mass	J:191963
	focal hair loss	J:191963
	gliosis	J:191963
	increased mitochondrial fission	J:191963
	increased variability of skeletal muscle fiber size	J:191963
	kyphosis	J:191963
	motor neuron degeneration	J:191963
	muscle weakness	J:191963
	myopathy	J:191963
	postnatal growth retardation	J:191963
	postnatal lethality, complete penetrance	J:191963
	skeletal muscle endomysial fibrosis	J:191963
	skeletal muscle fiber necrosis	J:191963

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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