Kcnma1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Kcnma1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
MGI:99923

44 phenotypes from 5 alleles in 8 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Kcnma1^em1(IMPC)H/Kcnma1^em1(IMPC)H C57BL/6N-Kcnma1^em1(IMPC)H/H	abnormal ear morphology	J:211773
	abnormal gait	J:211773
	abnormal locomotor behavior	J:211773
	increased circulating alkaline phosphatase level	J:211773
	tremors	J:211773
Kcnma1^em3Gpt/Kcnma1^em3Gpt involves: C57BL/6	abnormal podocyte morphology	J:325255
	abnormal podocyte physiology	J:325255
	abnormal renal protein reabsorption	J:325255
Kcnma1^tm1Ruth/Kcnma1^tm1Ruth 129-Kcnma1^tm1Ruth	abnormal cochlear IHC afferent innervation pattern	J:109217
	abnormal cochlear inner hair cell physiology	J:109217
	abnormal cochlear nerve fiber response	J:109217
	abnormal hearing electrophysiology	J:109217
	increased or absent distortion product otoacoustic emission threshold	J:109217
Kcnma1^tm1Ruth/Kcnma1^tm1Ruth involves: 129/Sv * C57BL/6	abnormal digestive system physiology	J:135743
	abnormal eye blink conditioning behavior	J:91427
	abnormal feces composition	J:135743
	abnormal gait	J:91427
	abnormal motor capabilities/coordination/movement	J:91427
	abnormal muscle contractility	J:148424
	abnormal postnatal growth	J:91427
	abnormal urinary bladder physiology	J:148424
	ataxia	J:91427
	impaired ability to fire action potentials	J:91427
	impaired coordination	J:91427
	impaired swimming	J:91427
	increased blinking frequency	J:91427
	increased muscle relaxation	J:148424
	increased synaptic depression	J:91427
	increased systemic arterial blood pressure	J:91427
	increased urination frequency	J:148424
	short stride length	J:91427
	tremors	J:91427
Kcnma1^tm1Ruth/Kcnma1^tm1Ruth involves: 129X1/SvJ	absent distortion product otoacoustic emissions	J:92443
	cochlear outer hair cell degeneration	J:92443, J:117764
	Deiters cell degeneration	J:92443
	increased apoptosis	J:92443
	increased susceptibility to noise-induced hearing loss	J:117764
	sensorineural hearing loss	J:92443
Kcnma1^tm1Ruth/Kcnma1^tm2.1Ruth X/Tg(Myh11-icre/ERT2)1Soff involves: 129/Sv * C57BL/6 * FVB/N	abnormal muscle contractility	J:148424
	abnormal urinary bladder physiology	J:148424
	increased urination frequency	J:148424
Kcnma1^tm1Rwa/Kcnma1^tm1Rwa FVB.129-Kcnma1^tm1Rwa	abnormal cochlear inner hair cell physiology	J:117811
	abnormal gait	J:92539
	abnormal urinary bladder physiology	J:92539
	ataxia	J:92539
	decreased body weight	J:92539
	decreased litter size	J:92539
	decreased susceptibility to noise-induced hearing loss	J:117811
	impaired coordination	J:92539
	increased urination frequency	J:92539
	premature death	J:92539
	short stride length	J:92539
	unidirectional circling	J:92539
	urinary incontinence	J:92539
Kcnma1^tm1Rwa/Kcnma1^tm1Rwa involves: 129S1/Sv * 129X1/SvJ	abnormal action potential	J:225860
Kcnma1^tm1Rwa/Kcnma1^tm1Rwa involves: 129S1/Sv * 129X1/SvJ	abnormal channel response	J:225860

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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