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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ighmbp2
immunoglobulin mu DNA binding protein 2
MGI:99954
79 phenotypes from 10 alleles in 8 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ighmbp2em1(IMPC)Tcp/Ighmbp2+
C57BL/6NCrl-Ighmbp2em1(IMPC)Tcp/Tcp 		abnormal skin morphology J:211773
decreased bone mineral content J:211773
enlarged kidney J:211773
Ighmbp2em1(IMPC)Tcp/Ighmbp2em1(IMPC)Tcp
C57BL/6NCrl-Ighmbp2em1(IMPC)Tcp/Tcp 		preweaning lethality, complete penetrance J:211773
Ighmbp2em1Cll/Ighmbp2em1Cll
FVB/NJ-Ighmbp2em1Cll 		abnormal coat appearance J:326540
abnormal neuromuscular synapse morphology J:326540
abnormal respiratory function J:326540
apnea J:326540
decreased body size J:326540
decreased body weight J:326540
decreased pulmonary respiratory rate J:326540
decreased pulmonary ventilation J:326540
decreased skeletal muscle fiber size J:326540
impaired righting response J:326540
increased tidal volume J:326540
motor neuron degeneration J:326540
muscular atrophy J:326540
postnatal lethality, complete penetrance J:326540
Ighmbp2em1Cx/Ighmbp2em1Cx
C57BL/6J-Ighmbp2em1Cx/Cx 		abnormal motor coordination/balance J:337488
abnormal neuromuscular synapse morphology J:337488
allodynia J:337488
axonal dystrophy J:337488
cachexia J:337488
normal cardiovascular system phenotype J:337488
decreased grip strength J:337488
decreased skeletal muscle weight J:337488
impaired coordination J:337488
increased thermal nociceptive threshold J:337488
muscular atrophy J:337488
paraparesis J:337488
skeletal muscle fiber atrophy J:337488
thin body J:337488
Ighmbp2em5Cx/Ighmbp2+
C57BL/6J-Ighmbp2em5Cx/Cx 		decreased nerve conduction velocity J:337488
Ighmbp2em5Cx/Ighmbp2em5Cx
C57BL/6J-Ighmbp2em5Cx/Cx 		abnormal motor coordination/balance J:337488
abnormal neuromuscular synapse morphology J:337488
axonal dystrophy J:337488
decreased body weight J:337488
decreased grip strength J:337488
decreased nerve conduction velocity J:337488
muscular atrophy J:337488
Ighmbp2nmd-2J/Ighmbp2nmd-2J
B6.BKS-Ighmbp2nmd-2J/J 		abnormal axon morphology J:92862
abnormal cardiovascular system physiology J:90418
abnormal cell cytoskeleton morphology J:92862
abnormal diaphragm morphology J:92862
abnormal heart morphology J:90418
abnormal heart valve morphology J:90418
abnormal heart ventricle morphology J:90418
abnormal impulse conducting system conduction J:90418
abnormal innervation pattern to muscle J:92862
abnormal intercalated disk morphology J:90418
abnormal myocardial fiber morphology J:90418
abnormal neuromuscular synapse morphology J:92862
abnormal QRS complex J:90418
abnormal Schwann cell morphology J:92862
cardiac interstitial fibrosis J:90418
centrally nucleated skeletal muscle fibers J:90418
decreased grip strength J:90418
decreased heart rate J:90418
decreased pulmonary respiratory rate J:90418
decreased systemic arterial systolic blood pressure J:90418
dilated cardiomyopathy J:90418
dilated heart atrium J:90418
dilated heart ventricle J:90418
increased circulating creatine kinase level J:90418
increased heart rate variability J:90418
increased variability of skeletal muscle fiber size J:90418
motor neuron degeneration J:90418
muscle degeneration J:90418
myocardial fiber degeneration J:90418
myocardium necrosis J:90418
pleural effusion J:90418
premature death J:90418
prolonged P wave J:90418
prolonged PR interval J:90418
pulmonary edema J:90418
skeletal muscle fiber atrophy J:90418
skeletal muscle interstitial fibrosis J:90418
thin ventricular wall J:90418
weight loss J:90418
Ighmbp2nmd-2J/Ighmbp2nmd-2J
BKS.Cg Dock7m +/+ Leprdb-Ighmbp2nmd-2J 		abnormal gait J:23584
abnormal grip strength J:23584
abnormal innervation pattern to muscle J:23584
abnormal masseter muscle morphology J:23584
abnormal skeletal muscle fiber morphology J:23584
abnormal temporalis muscle morphology J:23584
hindlimb paralysis J:23584
limb grasping J:23584
premature death J:23584
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Eno2-Ighmbp2)17Cx/?
involves: C57BL/6J * C57BLKS/J 		abnormal cardiovascular system physiology J:90418
abnormal impulse conducting system conduction J:90418
decreased pulmonary respiratory rate J:90418
dilated cardiomyopathy J:90418
increased circulating creatine kinase level J:90418
muscle degeneration J:90418
normal muscle phenotype J:90418
normal nervous system phenotype J:90418
pleural effusion J:90418
premature death J:90418
prolonged P wave J:90418
prolonged PR interval J:90418
prolonged QRS complex duration J:90418
pulmonary edema J:90418
weight loss J:90418
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Eno2-Ighmbp2)90Cx/?
involves: C57BL/6J * C57BLKS/J 		abnormal cardiovascular system physiology J:90418
abnormal impulse conducting system conduction J:90418
abnormal PR interval J:90418
abnormal QRS complex J:90418
decreased pulmonary respiratory rate J:90418
dilated cardiomyopathy J:90418
muscle degeneration J:90418
normal muscle phenotype J:90418
normal nervous system phenotype J:90418
premature death J:90418
prolonged P wave J:90418
pulmonary edema J:90418
weight loss J:90418
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Ttn-Ighmbp2)45Cx/?
involves: C57BL/6J * C57BLKS/J 		abnormal food intake J:102748
normal cardiovascular system phenotype J:102748
dysphagia J:102748
enlarged esophagus J:102748
motor neuron degeneration J:102748
muscle degeneration J:102748
premature death J:102748
weight loss J:102748
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Ttn-Ighmbp2)108Cx/?
involves: C57BL/6J * C57BLKS/J 		abnormal food intake J:102748
normal cardiovascular system phenotype J:102748
dysphagia J:102748
enlarged esophagus J:102748
motor neuron degeneration J:102748
muscle degeneration J:102748
premature death J:102748
weight loss J:102748
Ighmbp2nmd/Ighmbp2nmd
CBA/J-Ighmbp2nmd 		muscle degeneration J:23584
premature death J:23584
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory