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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ewsr1
Ewing sarcoma breakpoint region 1
MGI:99960
35 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ewsr1tm1(ERG)Thr/Ewsr1+
Rag1tm1(cre)Thr/Rag1+
involves: 129S/SvEv 		increased leukemia incidence J:98679
increased lymphocyte cell number J:98679
increased T cell derived lymphoma incidence J:98679
Ewsr1tm1Sblee/Ewsr1+
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		no abnormal phenotype detected J:156860
Ewsr1tm1Sblee/Ewsr1tm1Sblee
involves: 129S6/SvEvTac * Black Swiss 		abnormal cell nucleus morphology J:122058
abnormal male meiosis J:122058
abnormal ovary morphology J:122058
abnormal spermatid morphology J:122058
abnormal spermatocyte morphology J:122058
abnormal testis morphology J:122058
absent corpus luteum J:122058
absent mature ovarian follicles J:122058
absent subcutaneous adipose tissue J:122058
decreased body weight J:122058
decreased bone mineral density J:122058
decreased double-positive T cell number J:122058
decreased immature B cell number J:122058
decreased leukocyte cell number J:122058
decreased mature B cell number J:122058
decreased pre-B cell number J:122058
early cellular replicative senescence J:122058
female infertility J:122058
increased mortality induced by gamma-irradiation J:122058
kyphosis J:122058
male infertility J:122058
muscular atrophy J:122058
postnatal growth retardation J:122058
preweaning lethality, incomplete penetrance J:122058
small ovary J:122058
small testis J:122058
spleen hypoplasia J:122058
thymus hypoplasia J:122058
Ewsr1tm2(FLI1*)Sblee/Ewsr1+
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S6/SvEvTac * C57BL/6 * CBA 		increased fibroblast apoptosis J:156860
increased renal tubule apoptosis J:156860
premature death J:156860
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory