Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Cav1tm1Mls Name: caveolin 1, caveolae protein; targeted mutation 1, Michael P Lisanti MGI ID: MGI:2180364 Synonyms: cav-, Cav-1-, Cav-1 KO, Caveolin-1 KO, Cavtm1Mls Gene: Cav1  Location: Chr6:17306387-17341323 bp, + strand  Genetic Position: Chr6, 7.73 cM, cytoband A2 Alliance: Cav1tm1Mls page

Cav1tm1Mls/Cav1tm1Mls mice show lung abnormalities, with thickened alveolar septa and hypercellularity Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:75193
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 2.2 kb region of the gene including exons 1 and 2 and part of the promoter region was replaced with a neo resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by Western blot analysis of heart, adipose, and lung tissue, and also of mouse embryonic fibroblasts cultured from E13.5 homozygous mutant embryos. (J:75193)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	45 anatomical structure(s)

List all tumor models in MMHCdb carrying Cav1tm1Mls

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cav1 Mutation:	31 strains or lines available

Original:	J:75193 Razani B, et al., Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem. 2001 Oct 12;276(41):38121-38
All:	305 reference(s)