p-lambda-II-1
Probe Detail
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Name
p-lambda-II-1
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Sequence Type
cDNA
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ID
MGI:11837
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Region Covered
encodes gene segments Igl-V2, Igl-J2 and Igl-C2
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Vector Type
Plasmid
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Insert Site
PstI
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Insert Size
~.9 kb
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Note
This probe may hybridize to both Igl-C2 and Igl-C3 gene segments.
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Synonyms
p-lambda-2,
pAB-lambda-II,
pAB-lambda-II-1
|
Iglv1
|
immunoglobulin lambda variable 1
|
|
|
Igl-J
|
immunoglobulin lambda chain, joining region
|
|
|
Iglc2
|
immunoglobulin lambda constant 2
|
|
|
Iglv2
|
immunoglobulin lambda variable 2
|
|
J:20081
Kindt TJ, et al., Eur J Immunol. 1985 Jun;15(6):535-40
Notes: A PvuII/AvaII fragment encoding a portion of gene segment Igl-C2 was isolated from p[l]2 and used in Southern anaylsis.
| Endonuclease |
Gene |
Allele |
Fragments |
Strains |
| HindIII |
Iglc2 |
b |
3.5kb |
BALB/c |
| m |
18.0,15.0,9.0,3.5kb |
MOL |
| s |
9.5kb |
SPE |
J:9194
Hilbert DM, et al., J Immunol. 1988 Jun 15;140(12):4364-71
Notes: A 525 bp BglI fragment was isolated from p[l]II-1 and used in Southern analysis. The bands displayed are a composite of Igl-C2 and Igl-C3 fragments.
| Endonuclease |
Gene |
Allele |
Fragments |
Strains |
| BamHI |
Iglc2 |
b |
3.5,14.0kb |
BALB/c |
| c |
3.5,11.5,14.0kb |
CLA2/Cn |
J:6539
D'Eustachio P, et al., Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains. J Exp Med. 1981 Apr 1;153(4):793-800
J:6697
Alt F, et al., Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell. 1981 Dec;27(2 Pt 1):381-90
J:20008
Bothwell AL, et al., Dual expression of lambda genes in the MOPC-315 plasmacytoma. Nature. 1981 Mar 5;290(5801):65-7
J:6878
Francke U, et al., Comparative gene mapping: murine lambda light chain genes are located in region cen to B5 of mouse chromosome 16 not homologous to human chromosome 21. Cytogenet Cell Genet. 1982;33(3):267-71
J:20081
Kindt TJ, et al., Lambda light chain constant and variable gene complements in wild-derived inbred mouse strains. Eur J Immunol. 1985 Jun;15(6):535-40
J:8717
Dildrop R, et al., A new V gene expressed in lambda-2 light chains of the mouse. Eur J Immunol. 1987 May;17(5):731-4
J:9194
Hilbert DM, et al., Characterization of an inbred mouse exhibiting low responsiveness to phosphorylcholine. Antibodies from low-responder mice suggest gene conversion events within the S107VH gene family. J Immunol. 1988 Jun 15;140(12):4364-71
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