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cosmid 18.1 Probe Detail
Nucleotide
Probe/Clone
  • Name
    cosmid 18.1
  • Sequence Type
    genomic
  • ID
    MGI:13060
  • Region Covered
    encodes H-2D and flanking sequences
  • Vector Type
    Cosmid
  • Insert Site
    BglII
  • Insert Size
    ~36 kb
  • Synonyms
    C18.1
Source
  • Species
    mouse, laboratory
  • Strain
    BALB/c
  • Sex
    Male
  • Tissue
    sperm
Genes
H2-D1 histocompatibility 2, D region locus 1
Polymorphisms
J:7080 Winoto A, et al., Proc Natl Acad Sci U S A. 1983 Jun;80(11):3425-9
Notes: A 3.4 kb SmaI/NruI fragment was isolated from cosmid 18.1 and used in Southern analysis.
Endonuclease Gene Allele Fragments Strains
EcoRI H2-D1 a 25kb B6.Cg-H2b3/FlaCmwJ, B6.Cg-H2b4/FlaCmwJ, BALB/c, C57BL/6, C57BL/6-H2-T18a
b 12.3kb AKR, C57BL/6-H2k
c absent A.AL-H2a1, A.BY-H2bc H2-T18f/SnJ, A.TL-H2t1, A/WySnJ, B10.A-H2a, B10.A-H2h1/(1R), B10.A-H2i3/(3R), B10.AKM-H2m/SnJ, B10.BDR1-H2g4, B10.D2-H2d, B10.Q-H2q/SgJ, C3H, C57BL/10
HindIII H2-D1 a 13.5kb A.AL-H2a1, A/WySnJ, B10.A-H2i3/(3R), BALB/c
b 10.6kb B10.BDR1-H2g4, C3H, C57BL/6
c absent A.BY-H2bc H2-T18f/SnJ, A.TL-H2t1, AKR, AQR, B6.Cg-H2b3/FlaCmwJ, B6.Cg-H2b4/FlaCmwJ, B10.A-H2a, B10.A-H2h1/(1R), B10.AKM-H2m/SnJ, B10.D2-H2d, B10.Q-H2q/SgJ, C57BL/6-H2-T18a, C57BL/6-H2k, C57BL/10
References
J:6906 Goodenow RS, et al., Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer. Nature. 1982 Nov 18;300(5889):231-7
J:20104 Steinmetz M, et al., Clusters of genes encoding mouse transplantation antigens. Cell. 1982 Mar;28(3):489-98
J:7080 Winoto A, et al., Genetic mapping in the major histocompatibility complex by restriction enzyme site polymorphisms: most mouse class I genes map to the Tla complex. Proc Natl Acad Sci U S A. 1983 Jun;80(11):3425-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory