C1432 Probe Detail MGI Mouse MGI:13264

C1432 Probe Detail

Name

C1432
Sequence Type

genomic
ID

MGI:13264
Region Covered

encodes exons 7-8 and 3' flank sequence
Parent Clone

cosmid C1
Vector Type

Plasmid
Insert Site

PstI/SstI
Insert Size

0.45 kb
Note

Insert also exists in vector pBS.

Species

mouse, laboratory
Strain

C57BL/6
Tissue

liver

H2-Q	histocompatibility 2, Q region
H2-Q4	histocompatibility 2, Q region locus 4
H2-Q6	histocompatibility 2, Q region locus 6
H2-Q8	histocompatibility 2, Q region locus 8

J:7763 Flaherty L, et al., Proc Natl Acad Sci U S A. 1985 Mar;82(5):1503-7

Endonuclease	Gene	Allele	Fragments	Strains
XbaI	H2-Q	a	3.7kb	A, B6.Cg-H2^b4/FlaCmwJ, BALB/cFla, C57BL/6Fla, C57BL/6J, CAST/EiJ, MOLI/Ei
XbaI	H2-Q	b	absent	B6.Cg-H2^b3/FlaCmwJ, BALB/cBy, BALB/cKh-H2^dm2, C3H/HeJ

J:8531 O'Neill AE, et al., Immunogenetics. 1986;24(6):368-73

Notes: Because the H-2Q6 and H-2Q8 genes share many restriction sites, Southern analysis utilizing this probe and most restriction enzymes are unable to distinguish between the two loci.

Endonuclease	Gene	Allele	Fragments	Strains
BamHI	H2-Q4	a	8.8kb	B6.Cg-H2^b4/FlaCmwJ, C57BL/6
		b	5.9kb	B6.Cg-H2^b3/FlaCmwJ, BALB/cBy, BALB/cFla, CAST, MOLI, SWR/J
		c	6.6kb	A.SW-H2^s/Sn
		d	absent	A.CA-H2^f/Sn
BamHI	H2-Q6	a	5.9kb	A.SW-H2^s/Sn, B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
BamHI	H2-Q6	b	absent	A.CA-H2^f/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy
BamHI	H2-Q8	a	5.9kb	A.SW-H2^s/Sn, B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
BamHI	H2-Q8	b	absent	A.CA-H2^f/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy
BglII	H2-Q4	a	1.7kb	A.SW-H2^s/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.Cg-H2^b4/FlaCmwJ, BALB/cBy, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
BglII	H2-Q4	b	absent	A.CA-H2^f/Sn
BglII	H2-Q6	a	1.7kb	A.SW-H2^s/Sn, B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
BglII	H2-Q6	b	absent	A.CA-H2^f/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy
BglII	H2-Q8	a	1.7kb	A.SW-H2^s/Sn, B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
BglII	H2-Q8	b	absent	A.CA-H2^f/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy
EcoRI	H2-Q4	a	9.3kb	B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, C57BL/6
		b	14kb	B6.Cg-H2^b3/FlaCmwJ, B6.K4
		c	absent	A.CA-H2^f/Sn
EcoRI	H2-Q6	a	13.6kb	A.SW-H2^s/Sn, B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
EcoRI	H2-Q6	b	absent	A.CA-H2^f/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy
EcoRI	H2-Q8	a	13.6kb	A.SW-H2^s/Sn, B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
EcoRI	H2-Q8	b	absent	A.CA-H2^f/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy
HindIII	H2-Q4	a	10.2kb	B6.Cg-H2^b3/FlaCmwJ, B6.Cg-H2^b4/FlaCmwJ, BALB/cBy, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
		b	9.3kb	A.SW-H2^s/Sn
		c	absent	A.CA-H2^f/Sn
HindIII	H2-Q6	a	9.3kb	A.SW-H2^s/Sn, B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
HindIII	H2-Q6	b	absent	A.CA-H2^f/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy
HindIII	H2-Q8	a	9.3kb	A.SW-H2^s/Sn, B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
HindIII	H2-Q8	b	absent	A.CA-H2^f/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy
TaqI	H2-Q4	a	4.7kb	B6.Cg-H2^b3/FlaCmwJ, B6.Cg-H2^b4/FlaCmwJ, BALB/cBy, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
		b	5.4kb	A.SW-H2^s/Sn
		c	absent	A.CA-H2^f/Sn
TaqI	H2-Q6	a	2.8kb	A.SW-H2^s/Sn, B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
TaqI	H2-Q6	b	absent	A.CA-H2^f/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy
TaqI	H2-Q8	a	2.8kb	A.SW-H2^s/Sn, B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
TaqI	H2-Q8	b	absent	A.CA-H2^f/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy
XbaI	H2-Q4	a	10.6kb	B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, C57BL/6, MOLI
		b	13.4kb	B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy, BALB/cFla, CAST, SWR/J
		c	3.9kb	A.SW-H2^s/Sn
		d	absent	A.CA-H2^f/Sn
XbaI	H2-Q6	a	3.7kb	A.SW-H2^s/Sn, B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
XbaI	H2-Q6	b	absent	A.CA-H2^f/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy
XbaI	H2-Q8	a	3.7kb	A.SW-H2^s/Sn, B6.AC1, B6.AC2, B6.Cg-H2^b4/FlaCmwJ, B6.K3, BALB/cFla, C57BL/6, CAST, MOLI, SWR/J
XbaI	H2-Q8	b	absent	A.CA-H2^f/Sn, B6.Cg-H2^b3/FlaCmwJ, B6.K4, BALB/cBy

J:557 Uehara H, et al., Mamm Genome. 1991;1(2):92-9

Notes: t haplotype and strain designations appear in the allele groupings. This polymorphism appears to be due to the insertion of a 6.0 kb IAP-like element located in or near the H-2Q4 gene in mice with the b allele.

Endonuclease	Gene	Allele	Fragments	Strains
BamHI	H2-Q4	a	5.7kb	C3.t^w5, C3.t^w120, C3H
BamHI	H2-Q4	b	6.8kb	C3.t⁰, C3.t⁶, C3.t¹², C3.t^w1, C3.t^w8, C3.t^w12, C3.t^w73, STOCK t^w32

J:7763 Flaherty L, et al., Characterization of a Q subregion gene in the murine major histocompatibility complex. Proc Natl Acad Sci U S A. 1985 Mar;82(5):1503-7

J:8531 O'Neill AE, et al., Extensive deletions in the Q region of the mouse major histocompatibility complex. Immunogenetics. 1986;24(6):368-73

J:9093 Elliott E, et al., Novel mRNA species from a Q-subregion class-I gene of the murine major histocompatibility complex. Gene. 1987;61(2):189-98

J:557 Uehara H, et al., Molecular organization of the D-Qa region of t-haplotypes suggests that recombination is an important mechanism for generating genetic diversity of the major histocompatibility complex. Mamm Genome. 1991;1(2):92-9

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