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moPAH8 Probe Detail
Nucleotide
Probe/Clone
  • Name
    moPAH8
  • Sequence Type
    cDNA
  • ID
    MGI:15279
  • Region Covered
    47bp 5' untranslated region, 1359bp entire coding sequence, 572bp 3' untranslated region
  • Vector Type
    Phage
  • Insert Size
    1.98kb
Source
  • Species
    mouse, laboratory
  • Strain
    C57BL/6J
  • Tissue
    liver
Genes
Pah phenylalanine hydroxylase
Sequences
X51942 (GenBank | EMBL | ENA | DDBJ | MGI Sequence Detail)
Polymorphisms
J:10355 McDonald JD, et al., Proc Natl Acad Sci U S A. 1990 Mar;87(5):1965-7
Notes: Common fragments of sizes 10.0, 6.6, 4.9, 2.0, and 0.2 kb are also observed.
Endonuclease Gene Allele Fragments Strains
EcoRI Pah m 3.5kb M. m. domesticus, STOCK Pahenu1
s 10.1,3.6,3.4,2.8kb SPE/Pas
J:10899 Keller SA, et al., Proc Natl Acad Sci U S A. 1990 Dec;87(24):10019-22
Notes: Fragment sizes are for diagnostic bands only, other bands are present. Tg6208 is a transgenic line with a insertional mutation at the steel locus. A 1.9 kb EcoRI fragment of moPAH8 was used as the hybridization probe.
Endonuclease Gene Allele Fragments Strains
MspI Pah a 4.3,2.6kb C3H, TgN6208
b 4.0,2.4kb C57BL/6J
XbaI Pah a 2.3kb C3H, TgN6208
b 4.3kb C57BL/6J
J:3252 King TR, et al., Genomics. 1991 Oct;11(2):273-83
Endonuclease Gene Allele Fragments Strains
MspI Pah a 14.0kb BALB/cJ
c 7.3,7.8,16kb CAST/EiJ
J:3184 Shimizu A, et al., Biochem Genet. 1992 Oct;30(9-10):529-35
Notes: BamHI also detected an RFLP, but data not presented.
Endonuclease Gene Allele Fragments Strains
EcoRV Pah a 13.5,10.2,3.35kb 129X1/SvJ, AU/SsJ, BALB/cJ, C3H/He, C57BL/6J, CBA/ByA, DBA/2, DD/HeA, NC, NZB, SK/Cam
b 13.5,10.2,7.1,5.05,4.36kb M. m. molossinus
c not given CASA/RkJ
References
J:9202 Ledley FD, et al., Localization of mouse phenylalanine hydroxylase locus on chromosome 10. Cytogenet Cell Genet. 1988;47(3):125-6
J:10355 McDonald JD, et al., Pahhph-5: a mouse mutant deficient in phenylalanine hydroxylase. Proc Natl Acad Sci U S A. 1990 Mar;87(5):1965-7
J:10464 Ledley FD, et al., Mouse phenylalanine hydroxylase. Homology and divergence from human phenylalanine hydroxylase. Biochem J. 1990 Apr 15;267(2):399-405
J:10899 Keller SA, et al., Transgene-induced mutation of the murine steel locus. Proc Natl Acad Sci U S A. 1990 Dec;87(24):10019-22
J:3252 King TR, et al., Mapping anti-mullerian hormone (Amh) and related sequences in the mouse: identification of a new region of homology between MMU10 and HSA19p. Genomics. 1991 Oct;11(2):273-83
J:3184 Shimizu A, et al., A molecular genetic linkage map of mouse chromosome 10, including the Myb, S100b, Pah, Sl, and Ifg genes. Biochem Genet. 1992 Oct;30(9-10):529-35
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
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