V-beta-8 Probe Detail MGI Mouse MGI:9534

V-beta-8 Probe Detail

Name

V-beta-8
Sequence Type

genomic
ID

MGI:9534
Region Covered

S18.4 V beta region covering amino acid 13-95
Insert Size

246bp

Species

mouse, laboratory
Tissue

helper T-lymphocyte
Cell Line

S18.4

Trbv12-2	T cell receptor beta, variable 12-2
Tcrb-V8	T cell receptor beta, variable 8

J:7927 Sim GK, et al., Cell. 1985 Aug;42(1):89-92

Endonuclease	Gene	Allele	Fragments	Strains
EcoRI	Trbv12-2	+	4.2,5.0kb	AKR, B10.A-H2^a, BALB/c, C57BL/6
EcoRI	Trbv12-2	-	absent	C57BR, SJL/J, SWR/J
HindIII	Trbv12-2	+	9.5,1.0kb	AKR, B10.A-H2^a, BALB/c, C57BL/6
HindIII	Trbv12-2	-	absent	C57BR, SJL/J, SWR/J

J:10143 Nobuhara H, et al., Immunogenetics. 1989;30(6):405-13

Notes: Additional unique RFLP alleles were observed among wild strains and Mus subspecies.

Endonuclease	Gene	Allele	Fragments	Strains
EcoRI	Tcrb-V8	a	4.8,3.5,0.8kb	A/J, AKR/J, BALB/cAnN, C3H/HeJ, C57BL/6J, C57BL/10J, C58/J, CBA/J, DBA/1J, DBA/2J, I/LnJ, LP.RIIIS-H2^r/J, MA/MyJ, NZB/BlNJ, P/J, PL/J, RBF/DnJ, SL/Qdj, SM/J
EcoRI	Tcrb-V8	b	V[b]8 family deleted	AU/SsJ, C57L/J, RIIIS/J, SJL/J

J:10641 Vidard L, et al., Immunogenetics. 1990;32(1):27-33

Endonuclease	Gene	Allele	Fragments	Strains
EcoRI	Tcrb-V8	a	4.8,3.5,0.8kb	ABH, ABL, BALB/c
EcoRI	Tcrb-V8	b	- (deleted)	SJL/J

J:7927 Sim GK, et al., V beta gene polymorphism and a major polyclonal T cell receptor idiotype. Cell. 1985 Aug;42(1):89-92

J:10143 Nobuhara H, et al., Polymorphism of T-cell receptor genes among laboratory and wild mice: diverse origins of laboratory mice. Immunogenetics. 1989;30(6):405-13

J:10641 Vidard L, et al., Polymorphism of Tcrb and Tcrg genes in Biozzi mice: segregation analysis of a new Tcrg haplotype with antibody responsiveness. Immunogenetics. 1990;32(1):27-33

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