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Tbx2tm1.1(cre)Vmc - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tbx2tm1.1(cre)Vmc
T-box 2; targeted mutation 1.1, Vincent M Christoffels 		Driver: Tbx2
Type: Targeted (Recombinase)
Synonym: Tbx2Cre
Molecular description: Briefly, 5.9 kb of upstream and 2.2 kb of downstream Tbx2 129/SvJ genomic fragments were amplified by PCR and ligated to an Frt-flanked Cre-polyA-PGK-neo cassette replacing the first five codons of the Tbx2-coding region in exon 1. A diphteria toxin negative-selection cassette was placed at the 5' end of the targeting construct. Homologous recombination was performed in E14IB10 ES cells. The PGK-neo cassette in Tbx2CreNEO animals was removed subsequently by crossing with FlpE mice. Tbx2 expression is undetectable in homozygous embryos which show a similar hindlimb phenotype to that observed in Tbx2-deficient (Tbx2tm1Pa) embryos.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tbx2tm1.1(cre)Vmc activity also observed in:
endocrine system, head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:198684 Fig. s2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 15 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory