Sequence Detail

ID/Version

A0A0B4J1G0 Q8R477 Q3TC44 Q8R2R4 (UniProt | EBI)

Last sequence update: 2015-03-04
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Low affinity immunoglobulin gamma Fc region receptor III-A {ECO:0000250|UniProtKB:P08637}; Short=IgG Fc receptor III-A;AltName: Full=CD16-2 {ECO:0000303|PubMed:12389094};AltName: Full=FcgammaRIV {ECO:0000303|PubMed:16039578};AltName:

Provider

SWISS-PROT

Sequence

Polypeptide 249 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fcgr4	Fc receptor, IgG, low affinity IV	29	99	4	19

Sequence references in MGI

J:80483 Mechetina LV, et al., Identification of CD16-2, a novel mouse receptor homologous to CD16/Fc gamma RIII. Immunogenetics. 2002 Oct;54(7):463-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100540 Nimmerjahn F, et al., FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Immunity. 2005 Jul;23(1):41-51
J:123354 Hirano M, et al., IgEb immune complexes activate macrophages through FcgammaRIV binding. Nat Immunol. 2007 Jul;8(7):762-71
J:130906 Jakus Z, et al., Critical but overlapping role of FcgammaRIII and FcgammaRIV in activation of murine neutrophils by immobilized immune complexes. J Immunol. 2008 Jan 1;180(1):618-29
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:144620 Mancardi DA, et al., FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation. J Clin Invest. 2008 Nov;118(11):3738-50
J:155482 Syed SN, et al., Both FcgammaRIV and FcgammaRIII are essential receptors mediating type II and type III autoimmune responses via FcRgamma-LAT-dependent generation of C5a. Eur J Immunol. 2009 Dec;39(12):3343-56
J:206868 DiLillo DJ, et al., Broadly neutralizing hemagglutinin stalk-specific antibodies require FcgammaR interactions for protection against influenza virus in vivo. Nat Med. 2014 Feb;20(2):143-51
J:221858 Negishi-Koga T, et al., Immune complexes regulate bone metabolism through FcRgamma signalling. Nat Commun. 2015;6:6637
J:242013 Lehmann CHK, et al., DC subset-specific induction of T cell responses upon antigen uptake via Fcgamma receptors in vivo. J Exp Med. 2017 May 01;214(5):1509-1528