Sequence Detail

ID/Version

A2APX8 Q68V28 A2APX7 A2APX6 (UniProt | EBI)

Last sequence update: 2007-02-20
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Sodium channel protein type 1 subunit alpha;AltName: Full=Sodium channel protein brain I subunit alpha;AltName: Full=Sodium channel protein type I subunit alpha;AltName: Full=Voltage-gated sodium channel subunit alpha Nav1.1;

Provider

SWISS-PROT

Sequence

Polypeptide 2009 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Scn1a	sodium channel, voltage-gated, type I, alpha	56	106	4	27

Sequence references in MGI

J:109097 Haufe V, et al., Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart. J Physiol. 2005 May 1;564(Pt 3):683-96
J:113149 Yu FH, et al., Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat Neurosci. 2006 Sep;9(9):1142-9
J:125694 Kalume F, et al., Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy. J Neurosci. 2007 Oct 10;27(41):11065-74
J:161191 Martin MS, et al., Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J Biol Chem. 2010 Mar 26;285(13):9823-34
J:188126 Han S, et al., Autistic-like behaviour in Scn1a+/- mice and rescue by enhanced GABA-mediated neurotransmission. Nature. 2012 Sep 20;489(7416):385-90
J:189897 Cheah CS, et al., Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14646-51
J:235304 Osteen JD, et al., Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain. Nature. 2016 Jun 23;534(7608):494-9
J:242951 Sawyer NT, et al., Scn1a dysfunction alters behavior but not the effect of stress on seizure response. Genes Brain Behav. 2016 Mar;15(3):335-47
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89