ID/Version |
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Sequence description from provider |
RecName: Full=Low-density lipoprotein receptor-related protein 2; Short=LRP-2;AltName: Full=Glycoprotein 330; Short=gp330;AltName: Full=Megalin;Flags: Precursor; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
4660
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:53162
Nykjaer A, et al., An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell. 1999 Feb 19;96(4):507-15
J:67664 Hammad SM, et al., Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins. J Biol Chem. 2000 Apr 21;275(16):12003-8 J:95319 Spoelgen R, et al., LRP2/megalin is required for patterning of the ventral telencephalon. Development. 2005 Jan;132(2):405-14 J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563 J:104065 Faber K, et al., Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M. Mol Endocrinol. 2006 Jan;20(1):212-8 J:108391 Gonzalez-Villalobos R, et al., Megalin binds and internalizes angiotensin-(1-7). Am J Physiol Renal Physiol. 2006 May;290(5):F1270-5 J:115189 Hammes A, et al., Role of endocytosis in cellular uptake of sex steroids. Cell. 2005 Sep 9;122(5):751-62 J:121774 Kaseda R, et al., Megalin-mediated endocytosis of cystatin C in proximal tubule cells. Biochem Biophys Res Commun. 2007 Jun 15;357(4):1130-4 J:133662 Olson GE, et al., Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells. J Biol Chem. 2008 Mar 14;283(11):6854-60 J:134797 Konig O, et al., Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss. FASEB J. 2008 Feb;22(2):410-7 J:171318 Alvira-Botero X, et al., Megalin interacts with APP and the intracellular adapter protein FE65 in neurons. Mol Cell Neurosci. 2010 Nov;45(3):306-15 J:181474 Christ A, et al., LRP2 Is an Auxiliary SHH Receptor Required to Condition the Forebrain Ventral Midline for Inductive Signals. Dev Cell. 2012 Feb 14;22(2):268-78 J:183783 Ortega MC, et al., Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development. Glia. 2012 May;60(6):851-66 J:188910 Morris SM, et al., Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2. Traffic. 2001 Feb;2(2):111-23 J:200932 Jobst-Schwan T, et al., Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule. Am J Physiol Renal Physiol. 2013 Sep;305(5):F734-44 J:214694 Kur E, et al., LRP2 mediates folate uptake in the developing neural tube. J Cell Sci. 2014 May 15;127(Pt 10):2261-8 J:231312 Baardman ME, et al., Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. Dis Model Mech. 2016 Apr 1;9(4):413-25 J:239874 Christ A, et al., LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli. Dev Cell. 2015 Oct 12;35(1):36-48 J:243398 Gajera CR, et al., LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche. J Cell Sci. 2010 Jun 01;123(Pt 11):1922-30 J:243406 Gburek J, et al., Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin. Am J Physiol Renal Physiol. 2003 Sep;285(3):F451-8 J:243418 Johanns M, et al., Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2. Sci Rep. 2017 Jun 28;7(1):4328 J:248445 McCarthy RA, et al., Megalin functions as an endocytic sonic hedgehog receptor. J Biol Chem. 2002 Jul 12;277(28):25660-7 J:251304 Hirano M, et al., N-Glycoform-dependent interactions of megalin with its ligands. Biochim Biophys Acta. 2017 Jan;1861(1 Pt A):3106-3118 J:273590 Muramatsu H, et al., LDL receptor-related protein as a component of the midkine receptor. Biochem Biophys Res Commun. 2000 Apr 21;270(3):936-41 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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