Sequence Detail

ID/Version

A2AVA0 Q922H0 Q8CBT2 Q9ES77 Q9CUT3 Q8C720 (UniProt | EBI)

Last sequence update: 2008-02-05
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1;AltName: Full=Polydom;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 3567 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Svep1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	44	107	3	8

Sequence references in MGI

J:65975 Gilges D, et al., Polydom: a secreted protein with pentraxin, complement control protein, epidermal growth factor and von willebrand factor A domains. Biochem J. 2000 Nov 15;352 Pt 1:49-59
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:244466 Karpanen T, et al., An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation. Circ Res. 2017 Apr 14;120(8):1263-1275
J:255307 Samuelov L, et al., SVEP1 plays a crucial role in epidermal differentiation. Exp Dermatol. 2017 May;26(5):423-430
J:262023 Morooka N, et al., Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling. Circ Res. 2017 Apr 14;120(8):1276-1288
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:315946 Sato-Nishiuchi R, et al., Polydom/SVEP1 is a ligand for integrin alpha9beta1. J Biol Chem. 2012 Jul 20;287(30):25615-30
J:333698 Morris GE, et al., The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins alpha9beta1 and alpha4beta1. Br J Pharmacol. 2022 Nov;179(21):4958-4973
J:333810 Elenbaas JS, et al., SVEP1 is an endogenous ligand for the orphan receptor PEAR1. Nat Commun. 2023 Feb 15;14(1):850