Sequence Detail

ID/Version

B2RR83 (UniProt | EBI)

Last sequence update: 2008-07-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=3'-5' RNA helicase YTHDC2 {ECO:0000305}; EC=3.6.4.13 {ECO:0000269|PubMed:29360036};AltName: Full=Keen to exit meiosis leaving testes under-populated protein {ECO:0000303|PubMed:29360036}; Short=Ketu {ECO:0000303|PubMed:293600

Provider

SWISS-PROT

Sequence

Polypeptide 1445 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ythdc2	YTH domain containing 2	31	116	2	21

Sequence references in MGI

J:242348 Soh YQS, et al., Meioc maintains an extended meiotic prophase I in mice. PLoS Genet. 2017 Apr;13(4):e1006704
J:243742 Wojtas MN, et al., Regulation of m(6)A Transcripts by the 3'-->5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline. Mol Cell. 2017 Oct 19;68(2):374-387.e12
J:243743 Hsu PJ, et al., Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis. Cell Res. 2017 Sep;27(9):1115-1127
J:253477 Bailey AS, et al., The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline. Elife. 2017 Oct 31;6:e26116
J:256276 Jain D, et al., ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2. Elife. 2018 Jan 23;7:e30919
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306001 Zeng M, et al., Critical roles of mRNA m(6)A modification and YTHDC2 expression for meiotic initiation and progression in female germ cells. Gene. 2020 Aug 30;753:144810
J:335610 Qian B, et al., RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis. Sci Adv. 2022 Aug 26;8(34):eabq2945