ID/Version |
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Sequence description from provider |
RecName: Full=Histone acetyltransferase p300; Short=p300 HAT; EC=2.3.1.48 {ECO:0000269|PubMed:27105113};AltName: Full=E1A-associated protein p300;AltName: Full=Histone butyryltransferase p300; EC=2.3.1.- {ECO:0000269|PubMed:2710511 | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
2412
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:61379
Yahata T, et al., The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem. 2000 Mar 24;275(12):8825-34
J:95385 Cao D, et al., Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol. 2005 Jan;25(1):364-76 J:112873 Aikawa Y, et al., Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J. 2006 Sep 6;25(17):3955-65 J:132209 Mehra-Chaudhary R, et al., Msx3 protein recruits histone deacetylase to down-regulate the Msx1 promoter. Biochem J. 2001 Jan 1;353(Pt 1):13-22 J:148702 Ohoka N, et al., The orphan nuclear receptor ROR{alpha} restrains adipocyte differentiation through a reduction of C/EBP{beta} activity and perilipin gene expression. Mol Endocrinol. 2009 Jun;23(6):759-71 J:164308 Zhang M, et al., p300-mediated acetylation stabilizes the Th-inducing POK factor. J Immunol. 2010 Oct 1;185(7):3960-9 J:172915 Glenn DJ, et al., MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J Biol Chem. 1999 Dec 17;274(51):36159-67 J:172919 Mutoh H, et al., The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev. 1998 Mar 15;12(6):820-30 J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30 J:207820 Curtis AM, et al., Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. J Biol Chem. 2004 Feb 20;279(8):7091-7 J:215876 Wang FM, et al., Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation. Biochem J. 2011 Jan 1;433(1):245-52 J:219094 Cesena TI, et al., Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription. Mol Cell Endocrinol. 2008 Jul 16;289(1-2):94-101 J:222684 Wansa KD, et al., The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. J Biol Chem. 2003 Jul 4;278(27):24776-90 J:224721 Zhao Y, et al., p300-dependent acetylation of activating transcription factor 5 enhances C/EBPbeta transactivation of C/EBPalpha during 3T3-L1 differentiation. Mol Cell Biol. 2014 Feb;34(3):315-24 J:243518 Goudarzi A, et al., Dynamic Competing Histone H4 K5K8 Acetylation and Butyrylation Are Hallmarks of Highly Active Gene Promoters. Mol Cell. 2016 Apr 21;62(2):169-80 J:272987 Ryu D, et al., A SIRT7-dependent acetylation switch of GABPbeta1 controls mitochondrial function. Cell Metab. 2014 Nov 4;20(5):856-869 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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