Sequence Detail

ID/Version

D3Z291 (UniProt | EBI)

Last sequence update: 2010-04-20
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Calcium homeostasis modulator protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 348 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Calhm1	calcium homeostasis modulator 1	31	101	3	6

Sequence references in MGI

J:186424 Ma Z, et al., Calcium homeostasis modulator 1 (CALHM1) is the pore-forming subunit of an ion channel that mediates extracellular Ca2+ regulation of neuronal excitability. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):E1963-71
J:194915 Taruno A, et al., CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature. 2013 Mar 14;495(7440):223-6
J:244828 Wu J, et al., Generation of Calhm1 knockout mouse and characterization of calhm1 gene expression. Protein Cell. 2012 Jun;3(6):470-80
J:269649 Ma Z, et al., CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. Neuron. 2018 May 2;98(3):547-561.e10
J:286883 Kashio M, et al., CALHM1/CALHM3 channel is intrinsically sorted to the basolateral membrane of epithelial cells including taste cells. Sci Rep. 2019 Feb 25;9(1):2681
J:333223 Taruno A, et al., Post-translational palmitoylation controls the voltage gating and lipid raft association of the CALHM1 channel. J Physiol. 2017 Sep 15;595(18):6121-6145
J:347143 Okui M, et al., Posttranslational regulation of CALHM1/3 channel: N-linked glycosylation and S-palmitoylation. FASEB J. 2021 May;35(5):e21527