Sequence Detail

ID/Version

E9Q4Z2 Q6JIZ0 (UniProt | EBI)

Last sequence update: 2011-04-05
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Acetyl-CoA carboxylase 2 {ECO:0000250|UniProtKB:O00763}; EC=6.4.1.2 {ECO:0000250|UniProtKB:O00763};AltName: Full=ACC-beta {ECO:0000250|UniProtKB:O00763};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 2448 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Acacb	acetyl-Coenzyme A carboxylase beta	56	101	3	19

Sequence references in MGI

J:68427 Abu-Elheiga L, et al., Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 2001 Mar 30;291(5513):2613-6
J:96465 Oh W, et al., Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice. Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1384-9
J:109697 Abu-Elheiga L, et al., Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10207-12
J:138207 Essop MF, et al., Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice. Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H256-65
J:159285 Olson DP, et al., Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7598-603
J:184372 Abu-Elheiga L, et al., Acetyl-CoA carboxylase 2-/- mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions. J Biol Chem. 2012 Apr 6;287(15):12578-88
J:212818 Abu-Elheiga L, et al., The subcellular localization of acetyl-CoA carboxylase 2. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1444-9
J:212887 Kolwicz SC Jr, et al., Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy. Circ Res. 2012 Aug 31;111(6):728-38
J:214734 O'Neill HM, et al., AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice. Diabetologia. 2014 Aug;57(8):1693-702
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89