Sequence Detail

ID/Version

E9Q557 (UniProt | EBI)

Last sequence update: 2011-04-05
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Desmoplakin {ECO:0000312|MGI:MGI:109611}; Short=DP;

Provider

SWISS-PROT

Sequence

Polypeptide 2883 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dsp	desmoplakin	51	115	4	9

Sequence references in MGI

J:93314 Grossmann KS, et al., Requirement of plakophilin 2 for heart morphogenesis and cardiac junction formation. J Cell Biol. 2004 Nov 11;167(1):149-60
J:136451 Sklyarova T, et al., Plakophilin-3-deficient mice develop hair coat abnormalities and are prone to cutaneous inflammation. J Invest Dermatol. 2008 Jun;128(6):1375-85
J:182873 Jheon AH, et al., PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci. 2011 Mar 1;124(Pt 5):745-54
J:227218 Sharma P, et al., Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. Nat Commun. 2015;6:8391
J:233599 Rietscher K, et al., Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo. J Invest Dermatol. 2016 Jul;136(7):1471-8
J:238141 Keil R, et al., Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3. J Invest Dermatol. 2016 Oct;136(10):2022-9
J:243578 Lee P, et al., Phosphorylation of Pkp1 by RIPK4 regulates epidermal differentiation and skin tumorigenesis. EMBO J. 2017 Jul 03;36(13):1963-1980
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:310979 Dusek RL, et al., Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer. Breast Cancer Res. 2012 Apr 20;14(2):R65