Sequence Detail

ID/Version

O08530 Q9R235 Q9DC35 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Sphingosine 1-phosphate receptor 1 {ECO:0000305}; Short=S1P receptor 1; Short=S1P1 {ECO:0000303|PubMed:16314531};AltName: Full=Endothelial differentiation G-protein coupled receptor 1;AltName: Full=Lysophospholipid receptor B

Provider

SWISS-PROT

Sequence

Polypeptide 382 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	S1pr1	sphingosine-1-phosphate receptor 1	62	114	3	21

Sequence references in MGI

J:41657 Liu CH, et al., The mouse gene for the inducible G-protein-coupled receptor edg-1. Genomics. 1997 Jul 1;43(1):15-24
J:52870 Zhang G, et al., Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene. 1999 Feb 4;227(1):89-99
J:71961 Liu Y, et al., Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest. 2000 Oct;106(8):951-61
J:86450 Allende ML, et al., G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation. Blood. 2003 Nov 15;102(10):3665-7
J:89522 Allende ML, et al., Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J Biol Chem. 2004 Apr 9;279(15):15396-401
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:103755 Mizugishi K, et al., Essential role for sphingosine kinases in neural and vascular development. Mol Cell Biol. 2005 Dec;25(24):11113-21
J:120048 Rosenfeldt HM, et al., EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. FASEB J. 2001 Dec;15(14):2649-59
J:121194 Matloubian M, et al., Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature. 2004 Jan 22;427(6972):355-60
J:147106 Ishii M, et al., Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis. Nature. 2009 Mar 26;458(7237):524-8
J:173601 Poulsen RR, et al., The Sphingosine-1-phospate receptor 1 mediates S1P action during cardiac development. BMC Dev Biol. 2011;11:37
J:187683 Shoham AB, et al., S1P1 inhibits sprouting angiogenesis during vascular development. Development. 2012 Oct;139(20):3859-69
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89