Sequence Detail

ID/Version

O08574 Q3UIV5 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2024-05-29

Sequence description from provider

RecName: Full=Mesoderm posterior protein 2;

Provider

SWISS-PROT

Sequence

Polypeptide 370 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mesp2	mesoderm posterior 2	22	142	4	29

Sequence references in MGI

J:42014 Saga Y, et al., Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev. 1997 Jul 15;11(14):1827-39
J:54606 Barrantes IB, et al., Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol. 1999 May 6;9(9):470-80
J:62984 Kitajima S, et al., MesP1 and MesP2 are essential for the development of cardiac mesoderm. Development. 2000 Aug;127(15):3215-26
J:71693 Kume T, et al., The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 2001 Sep 15;15(18):2470-82
J:78989 Takahashi Y, et al., Mesp2 initiates somite segmentation through the Notch signalling pathway. Nat Genet. 2000 Aug;25(4):390-6
J:82125 Rhee J, et al., The protocadherin papc is involved in the organization of the epithelium along the segmental border during mouse somitogenesis. Dev Biol. 2003 Feb 15;254(2):248-61
J:84596 Takahashi Y, et al., Feedback loops comprising Dll1, Dll3 and Mesp2, and differential involvement of Psen1 are essential for rostrocaudal patterning of somites. Development. 2003 Sep;130(18):4259-68
J:98581 Morimoto M, et al., The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature. 2005 May 19;435(7040):354-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:110233 Nakajima Y, et al., Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2. Development. 2006 Jul;133(13):2517-25
J:119678 Morimoto M, et al., Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis. Dev Biol. 2006 Dec 15;300(2):687-98
J:120635 Takahashi Y, et al., Differential contributions of Mesp1 and Mesp2 to the epithelialization and rostro-caudal patterning of somites. Development. 2005 Feb;132(4):787-96
J:121562 Takahashi Y, et al., Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation. Dev Dyn. 2007 Jun;236(6):1484-94
J:122532 Takahashi Y, et al., Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation. Dev Biol. 2007 Apr 15;304(2):593-603
J:123846 Morimoto M, et al., The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite. Development. 2007 Apr;134(8):1561-9