Sequence Detail

ID/Version

O08583 Q0VBL5 Q9JJW7 Q8CBM4 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=THO complex subunit 4; Short=Tho4;AltName: Full=Ally of AML-1 and LEF-1;AltName: Full=Aly/REF export factor;AltName: Full=REF1-I;AltName: Full=RNA and export factor-binding protein 1;AltName: Full=Transcriptional coactivator Aly/REF;

Provider

SWISS-PROT

Sequence

Polypeptide 255 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Alyref	Aly/REF export factor	27	107	3	11

Sequence references in MGI

J:51741 Bruhn L, et al., ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. Genes Dev. 1997 Mar 1;11(5):640-53
J:65157 Stutz F, et al., REF, an evolutionary conserved family of hnRNP-like proteins, interacts with TAP/Mex67p and participates in mRNA nuclear export. RNA. 2000 Apr;6(4):638-50
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:205556 Christophorou MA, et al., Citrullination regulates pluripotency and histone H1 binding to chromatin. Nature. 2014 Mar 6;507(7490):104-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87
J:326230 Perez-Alvarado GC, et al., Structure of the nuclear factor ALY: insights into post-transcriptional regulatory and mRNA nuclear export processes. Biochemistry. 2003 Jun 24;42(24):7348-57