Sequence Detail

ID/Version

O08600 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Endonuclease G, mitochondrial; Short=Endo G; EC=3.1.30.-;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 294 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Endog	endonuclease G	41	100	3	8

Sequence references in MGI

J:43924 Prats E, et al., Characterization and expression of the mouse endonuclease G gene. DNA Cell Biol. 1997 Sep;16(9):1111-22
J:218272 Robertson AB, et al., Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination. Nucleic Acids Res. 2014 Dec 1;42(21):13280-93
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:301224 Wang W, et al., Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Nat Commun. 2021 Jan 20;12(1):476
J:313852 Park KH, et al., Crystal structure of the mouse endonuclease G. Biochem Biophys Res Commun. 2020 May 21;526(1):35-40
J:314088 Vander Zanden CM, et al., Structural adaptation of vertebrate endonuclease G for 5-hydroxymethylcytosine recognition and function. Nucleic Acids Res. 2020 Apr 17;48(7):3962-3974