Sequence Detail

ID/Version

O08689 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Growth/differentiation factor 8; Short=GDF-8;AltName: Full=Myostatin;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 376 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mstn	myostatin	54	115	3	32

Sequence references in MGI

J:40054 McPherron AC, et al., Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997 May 1;387(6628):83-90
J:85741 Hill JJ, et al., Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. Mol Endocrinol. 2003 Jun;17(6):1144-54
J:205290 Sartori R, et al., BMP signaling controls muscle mass. Nat Genet. 2013 Nov;45(11):1309-18
J:236214 Cash JN, et al., The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding. EMBO J. 2009 Sep 2;28(17):2662-76