Sequence Detail

ID/Version

O08691 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Arginase-2, mitochondrial; EC=3.5.3.1 {ECO:0000250|UniProtKB:P05089};AltName: Full=Arginase II;AltName: Full=Kidney-type arginase;AltName: Full=Non-hepatic arginase;AltName: Full=Type II arginase;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 354 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Arg2	arginase type II	38	103	3	10

Sequence references in MGI

J:48418 Iyer RK, et al., Cloning and characterization of the mouse and rat type II arginase genes. Mol Genet Metab. 1998 Mar;63(3):168-75
J:50121 Shi O, et al., Structure of the murine arginase II gene. Mamm Genome. 1998 Oct;9(10):822-4
J:237069 Xu W, et al., Increased mitochondrial arginine metabolism supports bioenergetics in asthma. J Clin Invest. 2016 Jul 01;126(7):2465-81
J:243479 Dunand-Sauthier I, et al., Repression of arginase-2 expression in dendritic cells by microRNA-155 is critical for promoting T cell proliferation. J Immunol. 2014 Aug 15;193(4):1690-700
J:243512 Geiger R, et al., L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Cell. 2016 Oct 20;167(3):829-842.e13
J:243519 Hardbower DM, et al., Arginase 2 deletion leads to enhanced M1 macrophage activation and upregulated polyamine metabolism in response to Helicobacter pylori infection. Amino Acids. 2016 Oct;48(10):2375-88
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89