Sequence Detail

ID/Version

O08747 Q8CD16 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Netrin receptor UNC5C;AltName: Full=Protein unc-5 homolog 3;AltName: Full=Protein unc-5 homolog C;AltName: Full=Rostral cerebellar malformation protein {ECO:0000303|PubMed:9126743};Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 931 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Unc5c	unc-5 netrin receptor C	38	120	4	14

Sequence references in MGI

J:40243 Ackerman SL, et al., The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein. Nature. 1997 Apr 24;386(6627):838-42
J:45577 Przyborski SA, et al., Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary. Development. 1998 Jan;125(1):41-50
J:80430 Finger JH, et al., The netrin 1 receptors unc5h3 and dcc are necessary at multiple choice points for the guidance of corticospinal tract axons. J Neurosci. 2002 Dec 1;22(23):10346-56
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:166034 Hong K, et al., A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell. 1999 Jun 25;97(7):927-41
J:224730 O'Sullivan ML, et al., FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. Neuron. 2012 Mar 8;73(5):903-10
J:227791 Wetzel-Smith MK, et al., A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death. Nat Med. 2014 Dec;20(12):1452-7
J:242688 Shao Q, et al., Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion. J Neurosci. 2017 Jun 07;37(23):5620-5633
J:269564 Purohit AA, et al., Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse. J Biol Chem. 2012 Aug 3;287(32):27126-38
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89