Sequence Detail

ID/Version

O09010 Q3U659 Q8K3F1 Q9DC10 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe {ECO:0000305}; EC=2.4.1.222 {ECO:0000269|PubMed:10935626, ECO:0000269|PubMed:16221665};AltName: Full=O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;

Provider

SWISS-PROT

Sequence

Polypeptide 378 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	19	180	3	14

Sequence references in MGI

J:41128 Johnston SH, et al., A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development. 1997 Jun;124(11):2245-54
J:41258 Cohen B, et al., Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. Nat Genet. 1997 Jul;16(3):283-8
J:48859 Evrard YA, et al., lunatic fringe is an essential mediator of somite segmentation and patterning. Nature. 1998 Jul 23;394(6691):377-81
J:54606 Barrantes IB, et al., Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. Curr Biol. 1999 May 6;9(9):470-80
J:55076 Moran JL, et al., Genomic structure, mapping, and expression analysis of the mammalian Lunatic, Manic, and Radical fringe genes. Mamm Genome. 1999 Jun;10(6):535-41
J:78344 Mustonen T, et al., Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth. Dev Biol. 2002 Aug 15;248(2):281-93
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:105687 Rampal R, et al., Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats. J Biol Chem. 2005 Dec 23;280(51):42454-63
J:205678 Sparrow DB, et al., Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. Am J Hum Genet. 2006 Jan;78(1):28-37
J:243509 Kakuda S, et al., Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands. Dev Cell. 2017 Jan 23;40(2):193-201