Sequence Detail

ID/Version

O09046 Q6Y632 Q3U7S6 Q1LZI6 Q3T9N9 Q8R2G8 Q9CXK7 Q6YDI8 Q3V0K2 Q6YBV6 (UniProt | EBI)

Last sequence update: 1997-07-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=L-amino-acid oxidase {ECO:0000305}; Short=LAAO {ECO:0000305}; Short=LAO {ECO:0000305}; EC=1.4.3.2 {ECO:0000269|PubMed:15383589}; EC=1.4.3.25 {ECO:0000250|UniProtKB:Q96RQ9};AltName: Full=Interleukin-4-induced p

Provider

SWISS-PROT

Sequence

Polypeptide 630 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il4i1	interleukin 4 induced 1	38	96	3	14

Sequence references in MGI

J:37359 Chu CC, et al., Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2507-12
J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
J:93725 Mason JM, et al., IL-4-induced gene-1 is a leukocyte L-amino acid oxidase with an unusual acidic pH preference and lysosomal localization. J Immunol. 2004 Oct 1;173(7):4561-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:229708 Cousin C, et al., The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation. Eur J Immunol. 2015 Jun;45(6):1772-82
J:244346 Yue Y, et al., IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production. PLoS One. 2015;10(11):e0142979
J:258123 Bod L, et al., IL-4-Induced Gene 1: A Negative Immune Checkpoint Controlling B Cell Differentiation and Activation. J Immunol. 2018 Feb 1;200(3):1027-1038
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:298785 Sadik A, et al., IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression. Cell. 2020 Sep 3;182(5):1252-1270.e34
J:302454 Lasoudris F, et al., IL4I1: an inhibitor of the CD8(+) antitumor T-cell response in vivo. Eur J Immunol. 2011 Jun;41(6):1629-38
J:302466 Bod L, et al., IL4-induced gene 1 promotes tumor growth by shaping the immune microenvironment in melanoma. Oncoimmunology. 2017;6(3):e1278331