Sequence Detail

ID/Version

O09161 O88505 Q56A03 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Calsequestrin-2;AltName: Full=Calsequestrin, cardiac muscle isoform;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 415 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Casq2	calsequestrin 2	38	114	3	17

Sequence references in MGI

J:50093 Park KW, et al., Cloning of the genes encoding mouse cardiac and skeletal calsequestrins: expression pattern during embryogenesis. Gene. 1998 Sep 14;217(1-2):25-30
J:114621 Knollmann BC, et al., Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. J Clin Invest. 2006 Sep;116(9):2510-20
J:124211 Song L, et al., Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia. J Clin Invest. 2007 Jul;117(7):1814-23
J:159954 Kalyanasundaram A, et al., The calsequestrin mutation CASQ2D307H does not affect protein stability and targeting to the junctional sarcoplasmic reticulum but compromises its dynamic regulation of calcium buffering. J Biol Chem. 2010 Jan 29;285(5):3076-83
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89