Sequence Detail

ID/Version

O35054 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Claudin-4 {ECO:0000303|PubMed:20921420};AltName: Full=Clostridium perfringens enterotoxin receptor {ECO:0000303|PubMed:9334247}; Short=CPE-R {ECO:0000303|PubMed:9334247}; Short=CPE-receptor {ECO:0000303|PubMed:9334247};

Provider

SWISS-PROT

Sequence

Polypeptide 210 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cldn4	claudin 4	45	117	7	8

Sequence references in MGI

J:43620 Katahira J, et al., Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo. J Biol Chem. 1997 Oct 17;272(42):26652-8
J:58914 Itoh M, et al., Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. J Cell Biol. 1999 Dec 13;147(6):1351-63
J:61744 Morita K, et al., Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):511-6
J:165532 Hou J, et al., Claudin-4 forms paracellular chloride channel in the kidney and requires claudin-8 for tight junction localization. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18010-5
J:220813 Gong Y, et al., KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4340-5