Sequence Detail

ID/Version

O35082 B2RR78 O70621 O70175 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Klotho; EC=3.2.1.31;Contains: RecName: Full=Klotho peptide;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1014 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kl	klotho	38	100	3	25

Sequence references in MGI

J:44109 Kuro-o M, et al., Mutation of the mouse klotho gene leads to a syndrome resembling ageing [see comments]. Nature. 1997 Nov 6;390(6655):45-51
J:46369 Shiraki-Iida T, et al., Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein. FEBS Lett. 1998 Mar 6;424(1-2):6-10
J:64878 Utsugi T, et al., Decreased insulin production and increased insulin sensitivity in the klotho mutant mouse, a novel animal model for human aging. Metabolism. 2000 Sep;49(9):1118-23
J:66078 Mori K, et al., Disruption of klotho gene causes an abnormal energy homeostasis in mice. Biochem Biophys Res Commun. 2000 Nov 30;278(3):665-70
J:86859 Tsujikawa H, et al., Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. Mol Endocrinol. 2003 Dec;17(12):2393-403
J:88858 Tohyama O, et al., Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J Biol Chem. 2004 Mar 12;279(11):9777-84
J:90278 Imura A, et al., Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett. 2004 Jun 7;565(1-3):143-7
J:101199 Kurosu H, et al., Suppression of aging in mice by the hormone Klotho. Science. 2005 Sep 16;309(5742):1829-33
J:101837 Li SA, et al., Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Cell Struct Funct. 2004 Dec;29(4):91-9
J:108907 Kamemori M, et al., Expression of Klotho protein in the inner ear. Hear Res. 2002 Sep;171(1-2):103-110
J:117479 Urakawa I, et al., Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature. 2006 Dec 7;444(7120):770-4
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89