Sequence Detail

ID/Version

O35111 O35163 (UniProt | EBI)

Last sequence update: 1998-08-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Potassium channel subfamily K member 3;AltName: Full=Acid-sensitive potassium channel protein TASK-1;AltName: Full=Cardiac two pore background K(+) channel;AltName: Full=TWIK-related acid-sensitive K(+) channel 1;AltName: Full=Two pore potas

Provider

SWISS-PROT

Sequence

Polypeptide 409 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Kcnk3	potassium channel, subfamily K, member 3	34	102	4	16

Sequence references in MGI

J:42969 Duprat F, et al., TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J. 1997 Sep 1;16(17):5464-71
J:51275 Kim D, et al., Cloning and functional expression of a novel cardiac two-pore background K+ channel (cTBAK-1). Circ Res. 1998 Mar 9;82(4):513-8
J:124944 Brickley SG, et al., TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons. J Neurosci. 2007 Aug 29;27(35):9329-40
J:130188 Heitzmann D, et al., Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis. EMBO J. 2008 Jan 9;27(1):179-87
J:130850 Mulkey DK, et al., TASK channels determine pH sensitivity in select respiratory neurons but do not contribute to central respiratory chemosensitivity. J Neurosci. 2007 Dec 19;27(51):14049-58
J:131927 Davies LA, et al., TASK channel deletion in mice causes primary hyperaldosteronism. Proc Natl Acad Sci U S A. 2008 Feb 12;105(6):2203-8
J:138786 Trapp S, et al., A role for TASK-1 (KCNK3) channels in the chemosensory control of breathing. J Neurosci. 2008 Aug 27;28(35):8844-50
J:248914 Chen Y, et al., Crosstalk between KCNK3-Mediated Ion Current and Adrenergic Signaling Regulates Adipose Thermogenesis and Obesity. Cell. 2017 Nov 02;171(4):836-848.e13
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89