Sequence Detail

ID/Version

O35134 Q7TSA9 (UniProt | EBI)

Last sequence update: 2004-12-07
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=DNA-directed RNA polymerase I subunit RPA1; Short=RNA polymerase I subunit A1; EC=2.7.7.6 {ECO:0000250|UniProtKB:O95602};AltName: Full=DNA-directed RNA polymerase I largest subunit;AltName: Full=DNA-directed RNA polymerase I

Provider

SWISS-PROT

Sequence

Polypeptide 1717 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Polr1a	polymerase (RNA) I polypeptide A	41	101	3	32

Sequence references in MGI

J:41855 Seither P, et al., Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I. Mol Gen Genet. 1997 Jun;255(2):180-6
J:268520 Zhang Q, et al., Evolutionarily-conserved MZIP2 is essential for crossover formation in mammalian meiosis. Commun Biol. 2018;1:147
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297328 Zhang Q, et al., SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I. Sci Adv. 2019 Jan;5(1):eaau9780
J:335489 Smallwood K, et al., POLR1A variants underlie phenotypic heterogeneity in craniofacial, neural, and cardiac anomalies. Am J Hum Genet. 2023 May 4;110(5):809-825
J:343402 Jansa P, et al., Mechanism of transcription termination: PTRF interacts with the largest subunit of RNA polymerase I and dissociates paused transcription complexes from yeast and mouse. Mol Gen Genet. 1999 Oct;262(3):508-14