Sequence Detail

ID/Version

O35177 Q99KE7 Q8BL52 Q8BJL8 Q8BM94 Q8BK90 Q8BMI9 (UniProt | EBI)

Last sequence update: 2003-06-20
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Enhancer of filamentation 1 {ECO:0000303|PubMed:10692442}; Short=mEF1 {ECO:0000303|PubMed:10692442};AltName: Full=CRK-associated substrate-related protein {ECO:0000312|EMBL:AAB71663.1}; Short=CAS-L {ECO:0000303|PubMed:2735929

Provider

SWISS-PROT

Sequence

Polypeptide 833 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9	51	105	3	7

Sequence references in MGI

J:60858 Sakakibara A, et al., Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways. J Biol Chem. 2000 Mar 3;275(9):6404-10
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:116716 Seo S, et al., Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance. J Immunol. 2005 Sep 15;175(6):3492-501
J:116755 Regelmann AG, et al., The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking. Immunity. 2006 Dec;25(6):907-18
J:152504 Near RI, et al., Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens. Mol Vis. 2009;15:685-99
J:168934 Garron ML, et al., Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance. J Mol Biol. 2009 Feb 13;386(1):190-203
J:229548 Knutson DC, et al., Mice null for NEDD9 (HEF1) display extensive hippocampal dendritic spine loss and cognitive impairment. Brain Res. 2016 Feb 1;1632:141-55
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:320065 Kozyreva VK, et al., NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. Mol Cancer Res. 2014 May;12(5):681-93
J:320154 Lee KH, et al., Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions. J Biol Chem. 2018 Jan 19;293(3):847-862
J:322366 Santos LC, et al., Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability. Immunol Cell Biol. 2016 Nov;94(10):981-993
J:322372 Bradbury P, et al., Src kinase determines the dynamic exchange of the docking protein NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesions. J Biol Chem. 2014 Sep 5;289(36):24792-800
J:322376 Omata Y, et al., Identification of Nedd9 as a TGF-beta-Smad2/3 Target Gene Involved in RANKL-Induced Osteoclastogenesis by Comprehensive Analysis. PLoS One. 2016;11(6):e0157992