Sequence Detail

ID/Version

O35188 O35933 Q91V44 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Fractalkine {ECO:0000303|PubMed:10382755}; Short=FK {ECO:0000303|PubMed:12569158};AltName: Full=ABCD-3 {ECO:0000303|PubMed:10508268};AltName: Full=C-X3-C motif chemokine 1 {ECO:0000303|PubMed:9479488};AltName: Full=CX3C membrane-anch

Provider

SWISS-PROT

Sequence

Polypeptide 395 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cx3cl1	C-X3-C motif chemokine ligand 1	113	106	2	13

Sequence references in MGI

J:40832 Pan Y, et al., Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature. 1997 Jun 5;387(6633):611-7
J:45964 Rossi DL, et al., Cloning and characterization of a new type of mouse chemokine. Genomics. 1998 Jan 15;47(2):163-70
J:56065 Kanazawa N, et al., Fractalkine and macrophage-derived chemokine: T cell-attracting chemokines expressed in T cell area dendritic cells. Eur J Immunol. 1999 Jun;29(6):1925-32
J:57682 Schaniel C, et al., Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation. Eur J Immunol. 1999 Sep;29(9):2934-47
J:68831 Cook DN, et al., Generation and analysis of mice lacking the chemokine fractalkine. Mol Cell Biol. 2001 May;21(9):3159-65
J:81822 Lesnik P, et al., Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis. J Clin Invest. 2003 Feb;111(3):333-40
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:145036 Landsman L, et al., CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood. 2009 Jan 22;113(4):963-72
J:263697 Haskell CA, et al., Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX3CR1-expressing cells is independent of G-protein activation. J Biol Chem. 1999 Apr 9;274(15):10053-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89