Sequence Detail

ID/Version

O35235 Q3TWY5 O35306 Q9JJK8 Q9JJK9 Q9R1Y0 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Tumor necrosis factor ligand superfamily member 11;AltName: Full=Osteoclast differentiation factor; Short=ODF;AltName: Full=Osteoprotegerin ligand; Short=OPGL;AltName: Full=Receptor activator of nuclear factor kappa-B ligand;

Provider

SWISS-PROT

Sequence

Polypeptide 316 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	82	116	3	33

Sequence references in MGI

J:43257 Wong BR, et al., TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem. 1997 Oct 3;272(40):25190-4
J:44239 Anderson DM, et al., A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature. 1997 Nov 13;390(6656):175-9
J:46850 Yasuda H, et al., Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3597-602
J:54447 Lacey DL, et al., Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 1998 Apr 17;93(2):165-76
J:54689 Kodaira K, et al., Cloning and characterization of the gene encoding mouse osteoclast differentiation factor. Gene. 1999 Apr 1;230(1):121-7
J:54896 Lum L, et al., Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. J Biol Chem. 1999 May 7;274(19):13613-8
J:68794 Ikeda T, et al., Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus. Endocrinology. 2001 Apr;142(4):1419-26
J:74744 Ito S, et al., Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. J Biol Chem. 2002 Feb 22;277(8):6631-6
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:141906 Mahoney DJ, et al., TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation. J Biol Chem. 2008 Sep 19;283(38):25952-62
J:175305 Lee HL, et al., High extracellular calcium-induced NFATc3 regulates the expression of receptor activator of NF-kappaB ligand in osteoblasts. Bone. 2011 Aug;49(2):242-9
J:196719 Linares GR, et al., Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation. J Bone Miner Res. 2012 Jul;27(7):1553-65
J:198051 Kim H, et al., Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. Cell Metab. 2013 Feb 5;17(2):249-60
J:228311 Decker CE, et al., Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15654-9
J:235251 Tiedemann K, et al., Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism. J Cell Sci. 2013 Sep 15;126(Pt 18):4187-94
J:245306 Nelson CA, et al., RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor. Structure. 2012 Nov 07;20(11):1971-82
J:322376 Omata Y, et al., Identification of Nedd9 as a TGF-beta-Smad2/3 Target Gene Involved in RANKL-Induced Osteoclastogenesis by Comprehensive Analysis. PLoS One. 2016;11(6):e0157992