Sequence Detail

ID/Version

O35284 A2RT86 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Basic leucine zipper transcriptional factor ATF-like;AltName: Full=B-cell-activating transcription factor; Short=B-ATF;

Provider

SWISS-PROT

Sequence

Polypeptide 125 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Batf	basic leucine zipper transcription factor, ATF-like	31	100	3	15

Sequence references in MGI

J:62034 Williams KL, et al., Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus. Eur J Immunol. 2001 May;31(5):1620-7
J:82013 Williams KL, et al., BATF transgenic mice reveal a role for activator protein-1 in NKT cell development. J Immunol. 2003 Mar 1;170(5):2417-26
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:150643 Schraml BU, et al., The AP-1 transcription factor Batf controls T(H)17 differentiation. Nature. 2009 Jul 16;460(7253):405-9
J:160935 Betz BC, et al., Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med. 2010 May 10;207(5):933-42
J:172119 Ise W, et al., The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol. 2011 Jun;12(6):536-43
J:176457 Kuroda S, et al., Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14885-9
J:178965 Rutz S, et al., Transcription factor c-Maf mediates the TGF-beta-dependent suppression of IL-22 production in T(H)17 cells. Nat Immunol. 2011 Dec;12(12):1238-45
J:188767 Tussiwand R, et al., Compensatory dendritic cell development mediated by BATF-IRF interactions. Nature. 2012 Oct 25;490(7421):502-7
J:188993 Ciofani M, et al., A validated regulatory network for th17 cell specification. Cell. 2012 Oct 12;151(2):289-303
J:189230 Li P, et al., BATF-JUN is critical for IRF4-mediated transcription in T cells. Nature. 2012 Oct 25;490(7421):543-6
J:190118 Glasmacher E, et al., A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. Science. 2012 Nov 16;338(6109):975-80
J:190258 Wang J, et al., A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell. 2012 Mar 2;148(5):1001-14
J:244647 Nurieva RI, et al., STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J Biol Chem. 2012 Mar 30;287(14):11234-9