Sequence Detail

ID/Version

O35379 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Multidrug resistance-associated protein 1 {ECO:0000305}; EC=7.6.2.2 {ECO:0000269|PubMed:9281595};AltName: Full=ATP-binding cassette sub-family C member 1;AltName: Full=Glutathione-S-conjugate-translocating ATPase ABCC1 {ECO:0000305};

Provider

SWISS-PROT

Sequence

Polypeptide 1528 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Abcc1	ATP-binding cassette, sub-family C member 1	85	102	3	22

Sequence references in MGI

J:34847 Stride BD, et al., Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter. Mol Pharmacol. 1996 Jun;49(6):962-71
J:43236 Stride BD, et al., Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Mol Pharmacol. 1997 Sep;52(3):344-53
J:44110 Wijnholds J, et al., Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein. Nat Med. 1997 Nov;3(11):1275-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:329937 Maltbaek JH, et al., ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP. Immunity. 2022 Oct 11;55(10):1799-1812.e4