Sequence Detail

ID/Version

O35678 Q9D9G8 Q3V2R0 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Monoglyceride lipase {ECO:0000312|MGI:MGI:1346042}; Short=MGL; EC=3.1.1.23 {ECO:0000269|PubMed:18096503, ECO:0000269|PubMed:20554061, ECO:0000269|PubMed:21454566, ECO:0000269|PubMed:9341166};AltName: Full=Monoacylglycerol lip

Provider

SWISS-PROT

Sequence

Polypeptide 303 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Mgll	monoglyceride lipase	36	101	3	15

Sequence references in MGI

J:51746 Karlsson M, et al., cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. J Biol Chem. 1997 Oct 24;272(43):27218-23
J:58761 Karlsson M, et al., Exon-intron organization and chromosomal localization of the mouse monoglyceride lipase gene. Gene. 2001 Jul 11;272(1-2):11-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:165274 Schlosburg JE, et al., Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat Neurosci. 2010 Sep;13(9):1113-9
J:166013 Comelli F, et al., The inhibition of monoacylglycerol lipase by URB602 showed an anti-inflammatory and anti-nociceptive effect in a murine model of acute inflammation. Br J Pharmacol. 2007 Nov;152(5):787-94
J:172679 Taschler U, et al., Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance. J Biol Chem. 2011 May 20;286(20):17467-77
J:217994 Blankman JL, et al., A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol. 2007 Dec;14(12):1347-56
J:273553 Heier C, et al., Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae. Biochim Biophys Acta. 2010 Sep;1801(9):1063-71
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89