Sequence Detail

ID/Version

O35718 P97803 Q3U7X5 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Suppressor of cytokine signaling 3 {ECO:0000305}; Short=SOCS-3;AltName: Full=Cytokine-inducible SH2 protein 3; Short=CIS-3;AltName: Full=Protein EF-10;

Provider

SWISS-PROT

Sequence

Polypeptide 225 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Socs3	suppressor of cytokine signaling 3	37	105	4	21

Sequence references in MGI

J:43735 Starr R, et al., A family of cytokine-inducible inhibitors of signalling. Nature. 1997 Jun 26;387(6636):917-21
J:44165 Fu X, et al., E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. Mol Cell Biol. 1997 Mar;17(3):1503-12
J:52380 Nicholson SE, et al., Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 1999 Jan 15;18(2):375-85
J:55721 Auernhammer CJ, et al., Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6964-9
J:57476 Marine JC, et al., SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell. 1999 Sep 3;98(5):617-27
J:83645 Croker BA, et al., SOCS3 negatively regulates IL-6 signaling in vivo. Nat Immunol. 2003 Jun;4(6):540-5
J:84845 Seki Y, et al., SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. Nat Med. 2003 Aug;9(8):1047-54
J:92393 Liu Y, et al., BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. J Biol Chem. 2004 Sep 3;279(36):37436-44
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113957 Seki Y, et al., Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13003-8
J:201263 Bergamin E, et al., Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. Structure. 2006 Aug;14(8):1285-92