Sequence Detail

ID/Version

O35949 (UniProt | EBI)

Last sequence update: 1998-01-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Very long chain fatty acid elongase 3 {ECO:0000255|HAMAP-Rule:MF_03203}; EC=2.3.1.199 {ECO:0000250|UniProtKB:Q9HB03, ECO:0000255|HAMAP-Rule:MF_03203};AltName: Full=3-keto acyl-CoA synthase Elovl3 {ECO:0000255|HAMAP-Rule:MF_03203};Alt

Provider

SWISS-PROT

Sequence

Polypeptide 271 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Elovl3	ELOVL fatty acid elongase 3	23	103	4	12

Sequence references in MGI

J:44636 Tvrdik P, et al., Cig30, a mouse member of a novel membrane protein gene family, is involved in the recruitment of brown adipose tissue. J Biol Chem. 1997 Dec 12;272(50):31738-46
J:57563 Tvrdik P, et al., Cig30 and Pitx3 genes are arranged in a partially overlapping tail-to-tail array resulting in complementary transcripts. J Biol Chem. 1999 Sep 10;274(37):26387-92
J:61900 Tvrdik P, et al., Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids. J Cell Biol. 2000 May 1;149(3):707-18
J:88477 Westerberg R, et al., Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem. 2004 Feb 13;279(7):5621-9
J:108322 Westerberg R, et al., ELOVL3 is an important component for early onset of lipid recruitment in brown adipose tissue. J Biol Chem. 2006 Feb 24;281(8):4958-68
J:244609 Zadravec D, et al., Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity. FASEB J. 2010 Nov;24(11):4366-77