Sequence Detail

ID/Version

O54724 Q2TAW6 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Caveolae-associated protein 1;AltName: Full=Cav-p60;AltName: Full=Cavin-1;AltName: Full=Polymerase I and transcript release factor;

Provider

SWISS-PROT

Sequence

Polypeptide 392 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cavin1	caveolae associated 1	37	104	4	15

Sequence references in MGI

J:48217 Jansa P, et al., Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. EMBO J. 1998 May 15;17(10):2855-64
J:67577 Miyoshi K, et al., Structure of the mouse stat 3/5 locus: evolution from drosophila to zebrafish to mouse. Genomics. 2001 Jan 15;71(2):150-5
J:121710 Jansa P, et al., The transcript release factor PTRF augments ribosomal gene transcription by facilitating reinitiation of RNA polymerase I. Nucleic Acids Res. 2001 Jan 15;29(2):423-9
J:131446 Hill MM, et al., PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell. 2008 Jan 11;132(1):113-24
J:143425 Liu L, et al., Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell Metab. 2008 Oct;8(4):310-7
J:150419 Bastiani M, et al., MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. J Cell Biol. 2009 Jun 29;185(7):1259-73
J:205741 Hansen CG, et al., Deletion of cavin genes reveals tissue-specific mechanisms for morphogenesis of endothelial caveolae. Nat Commun. 2013;4:1831
J:220363 Wei Z, et al., The N-terminal leucine-zipper motif in PTRF/cavin-1 is essential and sufficient for its caveolae-association. Biochem Biophys Res Commun. 2015 Jan 16;456(3):750-6
J:236400 Liu L, et al., PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges. Elife. 2016 Aug 16;5:e17508
J:241469 Mohan J, et al., Cavin3 interacts with cavin1 and caveolin1 to increase surface dynamics of caveolae. J Cell Sci. 2015 Mar 01;128(5):979-91
J:268029 Wei Z, et al., Fam198a, a member of secreted kinase, secrets through caveolae biogenesis pathway. Acta Biochim Biophys Sin (Shanghai). 2018 Oct 1;50(10):968-975
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:343402 Jansa P, et al., Mechanism of transcription termination: PTRF interacts with the largest subunit of RNA polymerase I and dissociates paused transcription complexes from yeast and mouse. Mol Gen Genet. 1999 Oct;262(3):508-14