Sequence Detail

ID/Version

O54863 Q6P8M9 (UniProt | EBI)

Last sequence update: 2011-09-21
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Testis-specific serine/threonine-protein kinase 2; Short=TSK-2; Short=TSK2; Short=TSSK-2; Short=Testis-specific kinase 2; EC=2.7.11.1 {ECO:0000269|PubMed:23599433};AltName: Full=Serine/threonine-protei

Provider

SWISS-PROT

Sequence

Polypeptide 358 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tssk2	testis-specific serine kinase 2	42	105	2	13

Sequence references in MGI

J:45029 Kueng P, et al., A novel family of serine/threonine kinases participating in spermiogenesis. J Cell Biol. 1997 Dec 29;139(7):1851-9
J:49211 Nayak S, et al., Immunohistochemical analysis of the expression of two serine-threonine kinases in the maturing mouse testis. Mech Dev. 1998 Jun;74(1-2):171-4
J:62058 Zuercher G, et al., A novel member of the testis specific serine kinase family, tssk-3, expressed in the leydig cells of sexually mature mice. Mech Dev. 2000 May;93(1-2):175-7
J:137693 Xu B, et al., TSKS concentrates in spermatid centrioles during flagellogenesis. Dev Biol. 2008 Jul 15;319(2):201-10
J:137707 Xu B, et al., Targeted deletion of Tssk1 and 2 causes male infertility due to haploinsufficiency. Dev Biol. 2008 Jul 15;319(2):211-22
J:140805 Zhang Z, et al., Phosphorylation of mouse sperm axoneme central apparatus protein SPAG16L by a testis-specific kinase, TSSK2. Biol Reprod. 2008 Jul;79(1):75-83
J:156758 Shang P, et al., Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases. J Cell Sci. 2010 Feb 1;123(Pt 3):331-9
J:175334 Li Y, et al., Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis. Mol Hum Reprod. 2011 Jan;17(1):42-56
J:263437 Jha KN, et al., Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility. J Biol Chem. 2013 Jun 7;288(23):16308-20