Sequence Detail

ID/Version

O54885 O88603 (UniProt | EBI)

Last sequence update: 1998-06-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=TYRO protein tyrosine kinase-binding protein {ECO:0000312|MGI:MGI:1277211};AltName: Full=DNAX-activation protein 12 {ECO:0000303|PubMed:9490415};AltName: Full=Killer-activating receptor-associated protein {ECO:0000303|PubMed:9852069};

Provider

SWISS-PROT

Sequence

Polypeptide 114 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tyrobp	TYRO protein tyrosine kinase binding protein	73	102	3	24

Sequence references in MGI

J:49202 Lanier LL, et al., Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells [see comments]. Nature. 1998 Feb 12;391(6668):703-7
J:49203 Smith KM, et al., Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J Immunol. 1998 Jul 1;161(1):7-10
J:51515 Tomasello E, et al., Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12. J Biol Chem. 1998 Dec 18;273(51):34115-9
J:57105 Bakker AB, et al., Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9792-6
J:73938 Chung DH, et al., Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. Eur J Immunol. 2002 Jan;32(1):59-66
J:80426 Gilfillan S, et al., NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol. 2002 Dec;3(12):1150-5
J:81823 Kaifu T, et al., Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J Clin Invest. 2003 Feb;111(3):323-32
J:84951 Kumagai H, et al., Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem Biophys Res Commun. 2003 Aug 1;307(3):719-29
J:92687 Rosen DB, et al., A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. J Immunol. 2004 Aug 15;173(4):2470-8
J:95161 Voehringer D, et al., CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. J Biol Chem. 2004 Dec 24;279(52):54117-23
J:96626 Takahashi K, et al., Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med. 2005 Feb 21;201(4):647-57
J:110786 Takegahara N, et al., Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat Cell Biol. 2006 Jun;8(6):615-22
J:111212 Humphrey MB, et al., The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J Bone Miner Res. 2004 Feb;19(2):224-34
J:116120 Mocsai A, et al., Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol. 2006 Dec;7(12):1326-33
J:124243 Yotsumoto K, et al., Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. J Exp Med. 2003 Jul 21;198(2):223-33
J:130085 Yamanishi Y, et al., Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells. Blood. 2008 Jan 15;111(2):688-98
J:139490 Zou W, et al., DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk. Mol Cell. 2008 Aug 8;31(3):422-31
J:140167 Wakselman S, et al., Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor. J Neurosci. 2008 Aug 6;28(32):8138-43
J:142632 Nakahashi C, et al., Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRgamma chain on peritoneal macrophages. J Immunol. 2007 Jan 15;178(2):765-70
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:168989 Sumpter TL, et al., DAP12 Promotes IRAK-M Expression and IL-10 Production by Liver Myeloid Dendritic Cells and Restrains Their T Cell Allostimulatory Ability. J Immunol. 2011 Feb 15;186(4):1970-80
J:177613 Nakano-Yokomizo T, et al., The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses. J Exp Med. 2011 Aug 1;208(8):1661-71
J:219772 Diefenbach A, et al., Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat Immunol. 2002 Dec;3(12):1142-9
J:221150 Kobayashi M, et al., A DAP12-Dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons. Glia. 2015 Jun;63(6):1073-82
J:258167 Helming L, et al., Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. Sci Signal. 2008 Oct 28;1(43):ra11
J:260524 Zhao Y, et al., TREM2 Is a Receptor for beta-Amyloid that Mediates Microglial Function. Neuron. 2018 Mar 7;97(5):1023-1031.e7
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89