ID/Version |
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Sequence description from provider |
RecName: Full=TYRO protein tyrosine kinase-binding protein {ECO:0000312|MGI:MGI:1277211};AltName: Full=DNAX-activation protein 12 {ECO:0000303|PubMed:9490415};AltName: Full=Killer-activating receptor-associated protein {ECO:0000303|PubMed:9852069}; | ||||||||||||||
Provider | SWISS-PROT | ||||||||||||||
Sequence |
Polypeptide
114
aa
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Annotated genes and markers |
Follow the symbol links to get more information on the GO terms,
expression assays, orthologs, phenotypic alleles, and other information
for the genes or markers below.
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Sequence references in MGI |
J:49202
Lanier LL, et al., Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells [see comments]. Nature. 1998 Feb 12;391(6668):703-7
J:49203 Smith KM, et al., Ly-49D and Ly-49H associate with mouse DAP12 and form activating receptors. J Immunol. 1998 Jul 1;161(1):7-10 J:51515 Tomasello E, et al., Gene structure, expression pattern, and biological activity of mouse killer cell activating receptor-associated protein (KARAP)/DAP-12. J Biol Chem. 1998 Dec 18;273(51):34115-9 J:57105 Bakker AB, et al., Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9792-6 J:73938 Chung DH, et al., Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. Eur J Immunol. 2002 Jan;32(1):59-66 J:80426 Gilfillan S, et al., NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat Immunol. 2002 Dec;3(12):1150-5 J:81823 Kaifu T, et al., Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J Clin Invest. 2003 Feb;111(3):323-32 J:84951 Kumagai H, et al., Identification and characterization of a new pair of immunoglobulin-like receptors LMIR1 and 2 derived from murine bone marrow-derived mast cells. Biochem Biophys Res Commun. 2003 Aug 1;307(3):719-29 J:92687 Rosen DB, et al., A Structural basis for the association of DAP12 with mouse, but not human, NKG2D. J Immunol. 2004 Aug 15;173(4):2470-8 J:95161 Voehringer D, et al., CD200 receptor family members represent novel DAP12-associated activating receptors on basophils and mast cells. J Biol Chem. 2004 Dec 24;279(52):54117-23 J:96626 Takahashi K, et al., Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med. 2005 Feb 21;201(4):647-57 J:111212 Humphrey MB, et al., The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J Bone Miner Res. 2004 Feb;19(2):224-34 J:116120 Mocsai A, et al., Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat Immunol. 2006 Dec;7(12):1326-33 J:124243 Yotsumoto K, et al., Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. J Exp Med. 2003 Jul 21;198(2):223-33 J:130085 Yamanishi Y, et al., Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells. Blood. 2008 Jan 15;111(2):688-98 J:139490 Zou W, et al., DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk. Mol Cell. 2008 Aug 8;31(3):422-31 J:140167 Wakselman S, et al., Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor. J Neurosci. 2008 Aug 6;28(32):8138-43 J:142632 Nakahashi C, et al., Dual assemblies of an activating immune receptor, MAIR-II, with ITAM-bearing adapters DAP12 and FcRgamma chain on peritoneal macrophages. J Immunol. 2007 Jan 15;178(2):765-70 J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54 J:168989 Sumpter TL, et al., DAP12 Promotes IRAK-M Expression and IL-10 Production by Liver Myeloid Dendritic Cells and Restrains Their T Cell Allostimulatory Ability. J Immunol. 2011 Feb 15;186(4):1970-80 J:177613 Nakano-Yokomizo T, et al., The immunoreceptor adapter protein DAP12 suppresses B lymphocyte-driven adaptive immune responses. J Exp Med. 2011 Aug 1;208(8):1661-71 J:219772 Diefenbach A, et al., Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat Immunol. 2002 Dec;3(12):1142-9 J:221150 Kobayashi M, et al., A DAP12-Dependent signal promotes pro-inflammatory polarization in microglia following nerve injury and exacerbates degeneration of injured neurons. Glia. 2015 Jun;63(6):1073-82 J:258167 Helming L, et al., Essential role of DAP12 signaling in macrophage programming into a fusion-competent state. Sci Signal. 2008 Oct 28;1(43):ra11 J:260524 Zhao Y, et al., TREM2 Is a Receptor for beta-Amyloid that Mediates Microglial Function. Neuron. 2018 Mar 7;97(5):1023-1031.e7 J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89 |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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