Sequence Detail

ID/Version

O54890 Q3TZC6 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-11-27

Sequence description from provider

RecName: Full=Integrin beta-3 {ECO:0000305};AltName: Full=Platelet membrane glycoprotein IIIa {ECO:0000305}; Short=GPIIIa;AltName: CD_antigen=CD61;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 787 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Itgb3	integrin beta 3	194	111	4	16

Sequence references in MGI

J:86753 Nakamura T, et al., Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature. 2002 Jan 10;415(6868):171-5
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:134768 Montanez E, et al., Kindlin-2 controls bidirectional signaling of integrins. Genes Dev. 2008 May 15;22(10):1325-30
J:150774 Yang H, et al., Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression. Blood. 2009 Jul 9;114(2):425-36
J:230357 Calderwood DA, et al., Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2272-7
J:250837 Dohn MR, et al., The Gain-of-Function Integrin beta3 Pro33 Variant Alters the Serotonin System in the Mouse Brain. J Neurosci. 2017 Nov 15;37(46):11271-11284
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:292533 Wang L, et al., Cyclophilin A is an important mediator of platelet function by regulating integrin alphaIIbbeta3 bidirectional signalling. Thromb Haemost. 2014 May 5;111(5):873-82
J:296155 Castells MC, et al., gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation. Nat Immunol. 2001 May;2(5):436-42
J:313953 Fukao S, et al., gp49B-mediated negative regulation of antibody production by memory and marginal zone B cells. J Immunol. 2014 Jul 15;193(2):635-44
J:343322 Park S, et al., Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss. Metabolism. 2023 Nov 26;151:155746