Sequence Detail

ID/Version

O54943 O54954 (UniProt | EBI)

Last sequence update: 1999-07-15
Last annotation update: 2024-07-24

Sequence description from provider

RecName: Full=Period circadian protein homolog 2; Short=mPER2;AltName: Full=Circadian clock protein PERIOD 2;

Provider

SWISS-PROT

Sequence

Polypeptide 1257 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Per2	period circadian clock 2	96	128	3	31

Sequence references in MGI

J:44820 Albrecht U, et al., A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell. 1997 Dec 26;91(7):1055-64
J:45182 Shearman LP, et al., Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron. 1997 Dec;19(6):1261-9
J:51392 Sangoram AM, et al., Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron. 1998 Nov;21(5):1101-13
J:69626 Bae K, et al., Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock. Neuron. 2001 May;30(2):525-36
J:73173 Vielhaber EL, et al., Nuclear Export of Mammalian PERIOD Proteins. J Biol Chem. 2001 Dec 7;276(49):45921-7
J:73655 Lee C, et al., Posttranslational mechanisms regulate the mammalian circadian clock. Cell. 2001 Dec 28;107(7):855-67
J:87576 Lee C, et al., Direct association between mouse PERIOD and CKIepsilon is critical for a functioning circadian clock. Mol Cell Biol. 2004 Jan;24(2):584-94
J:106987 Chaves I, et al., Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance. Mol Cell Biol. 2006 Mar;26(5):1743-53
J:113744 Yelamanchili SV, et al., Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2. J Biol Chem. 2006 Jun 9;281(23):15671-9
J:116444 Etchegaray JP, et al., The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28;281(30):21209-15
J:120341 Ohno T, et al., The negative transcription factor E4BP4 is associated with circadian clock protein PERIOD2. Biochem Biophys Res Commun. 2007 Mar 23;354(4):1010-5
J:135908 Viswambharan H, et al., Mutation of the circadian clock gene Per2 alters vascular endothelial function. Circulation. 2007 Apr 24;115(16):2188-95
J:139296 Asher G, et al., SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell. 2008 Jul 25;134(2):317-28
J:150148 Etchegaray JP, et al., Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol. 2009 Jul;29(14):3853-66
J:150484 Hennig S, et al., Structural and functional analyses of PAS domain interactions of the clock proteins Drosophila PERIOD and mouse PERIOD2. PLoS Biol. 2009 Apr 28;7(4):e94
J:154857 Chen R, et al., Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Mol Cell. 2009 Nov 13;36(3):417-30
J:154880 Sasaki M, et al., Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. J Biol Chem. 2009 Sep 11;284(37):25149-59
J:156994 Schmutz I, et al., The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev. 2010 Feb 15;24(4):345-57
J:166433 Ohsaki K, et al., The role of {beta}-TrCP1 and {beta}-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2. J Biochem. 2008 Nov;144(5):609-18
J:167907 Grimaldi B, et al., PER2 controls lipid metabolism by direct regulation of PPARgamma. Cell Metab. 2010 Nov 3;12(5):509-20
J:173532 Duong HA, et al., A molecular mechanism for circadian clock negative feedback. Science. 2011 Jun 17;332(6036):1436-9
J:174435 Schmutz I, et al., Protein Phosphatase 1 (PP1) Is a Post-Translational Regulator of the Mammalian Circadian Clock. PLoS One. 2011;6(6):e21325
J:176743 Koyanagi S, et al., cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene. J Biol Chem. 2011 Sep 16;286(37):32416-23
J:177139 Lee HM, et al., The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16451-6
J:177241 Ozber N, et al., Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction. BMC Mol Biol. 2010;11:69
J:181918 Miki T, et al., PML regulates PER2 nuclear localization and circadian function. EMBO J. 2012;31(6):1427-39
J:183929 Zhao Y, et al., Loss of mPer2 increases plasma insulin levels by enhanced glucose-stimulated insulin secretion and impaired insulin clearance in mice. FEBS Lett. 2012 May 7;586(9):1306-11
J:185950 Padmanabhan K, et al., Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. 2012 Aug 3;337(6094):599-602
J:189236 Kowalska E, et al., Distinct Roles of DBHS Family Members in the Circadian Transcriptional Feedback Loop. Mol Cell Biol. 2012 Nov;32(22):4585-94
J:198214 Barclay JL, et al., High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice. Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1053-63
J:200473 Schneider K, et al., CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions. EMBO Rep. 2012 Dec;13(12):1138-44
J:204645 Zhao WN, et al., CIPC is a mammalian circadian clock protein without invertebrate homologues. Nat Cell Biol. 2007 Mar;9(3):268-75
J:205048 Richards J, et al., A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1697-704
J:205586 Annayev Y, et al., Gene model 129 (gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. J Biol Chem. 2014 Feb 21;289(8):5013-24
J:205840 Bonney S, et al., Cardiac Per2 functions as novel link between fatty acid metabolism and myocardial inflammation during ischemia and reperfusion injury of the heart. PLoS One. 2013;8(8):e71493
J:209477 Ye R, et al., Biochemical analysis of the canonical model for the mammalian circadian clock. J Biol Chem. 2011 Jul 22;286(29):25891-902
J:209490 Brown SA, et al., PERIOD1-associated proteins modulate the negative limb of the mammalian circadian oscillator. Science. 2005 Apr 29;308(5722):693-6
J:210023 Duong HA, et al., Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat Struct Mol Biol. 2014 Feb;21(2):126-32
J:210938 Yagita K, et al., Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein. EMBO J. 2002 Mar 15;21(6):1301-14
J:212062 Engelen E, et al., Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock. PLoS One. 2013;8(2):e56623
J:215866 Devos J, et al., Magel2, a Prader-Willi syndrome candidate gene, modulates the activities of circadian rhythm proteins in cultured cells. J Circadian Rhythms. 2011;9(1):12
J:244091 Noh JY, et al., Presence of multiple peripheral circadian oscillators in the tissues controlling voiding function in mice. Exp Mol Med. 2014 Mar 07;46:e81
J:266073 Toledo M, et al., Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1. Cell Metab. 2018 Aug 7;28(2):268-281.e4
J:291806 Sun S, et al., Sirt6 deacetylase activity regulates circadian rhythms via Per2. Biochem Biophys Res Commun. 2019 Apr 2;511(2):234-238
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:320290 Vielhaber E, et al., Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon. Mol Cell Biol. 2000 Jul;20(13):4888-99